Medical School:

• University of Iowa, Iowa City, IA

Residency:

• University of Iowa, Iowa City, IA

Fellowship:

• NIH Fellow, Mayo Clinic, Rochester MN (Digestive Disease)

Certification:

• American Board of Surgery

Societies, Organizations, and Honors:

• Association of Academic Surgery
• American Board of Surgery
• American College of Surgeons
• Association of VA Surgeons
• Midwest GUT Club
• American Gastroenterological Association
• Society for Surgery of the Alimentary Tract
• Surgery Biology Club III
• Society of University Surgeons
• American Society of Gastrointestinal Endoscopic Surgery
• Society of Free Radical Biology and Medicine (formerly Oxygen Society)
• University of Iowa Career Development Award - 2003
• Australian/New Zealand Chapter of the American College of Surgeons Traveling Fellowship - 2004

Selected Recent Publications:

• TM Perl, JJ Cullen, RP Wenzel, MB Zimmerman, MA Phaller, D Sheppard, J Twombley, P French, LA Herwaldt, and the Mupirocin and the Risk of Staphylococcus Aureus study team. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. New England Journal of Medicine 346:1871-1877, 2002.
• JJ Cullen, CA Weydert, MM Hinkhouse, JM Ritchie, FE Domann, DR Spitz, LW Oberley. The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Research 63:1297-1303, 2003.
• C Weydert, B Roling, J Liu, MM Hinkhouse, JM Ritchie, LW Oberley, JJ Cullen. Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase. Molecular Cancer Therapeutics 2:361-369, 2003.
• JJ Cullen, MM Hinkhouse, M Grady, AW Gaut, J Liu, Y Zhang, CJD Weydert, FE Domann, LW Oberley. Dicumarol inhibition of NAD(P)H:quinone oxidoreductase (NQO1) induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism. Cancer Research 63:5513-5520, 2003.
• Fitzgerald M, Oshiro M, Holtan N, Krager K, Cullen JJ, Futscher BW, Domann FE. Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control. Neoplasia 5:427-436, 2003.
• Liu J, Hinkhouse MM, Sun W, Weydert CJ, Ritchie JM, Oberley LW, Cullen JJ. Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype. Human Gene Therapy, 15:239-250, 2004.
• Lewis A, Ough M, Li L, Hinkhouse MM, Ritchie JM, Spitz DR, Cullen JJ. Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress. Clinical Cancer Research 10:4550-4558, 2004.
• Ough M, Lewis A, Zhang YP, Hinkhouse MM, Ritchie JM, Oberley LW, Cullen JJ. Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radical Research 38:1223-1233, 2004.
• Ough M, Lewis A, Bey EA, Gao JM, Boornman WJ, Ritchie JM, Boothman DA, Oberley LW, Cullen JJ. Efficacy of ?-lapachone in pancreatic cancer treatment: Exploiting the novel, therapeutic target NQO1. Cancer Biology and Therapy 4:95-102, 2005.
• Cullen JJ, Liu J, Weydert CJ, Oberley LW. Role of antioxidant enzymes in the growth of pancreatic adenocarcinoma. IN: Pancreatic Cancer: New Research, edited by Maxwell A. Loft. Nova Science Publishers, Inc., Hauppage, NY, pp. 1-28, 2005.
• Lewis A, Ough M, Du J, Tsao MS, Oberley LW, Cullen JJ. Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer. Molecular Carcinogenesis 43:215-224, 2005.
• Liu J, Du J, Zhang Y, Sun W, Smith BJ, Oberley LW, Cullen JJ. Suppression of the malignant phenotype in pancreatic cancer by the overexpression of phospholipid hydroperoxide glutathione peroxidase (PhGPx). Human Gene Therapy 17:105-116, 2006.
• Lewis A, Du, J, Liu J, Ritchie JM, Oberley LW, Cullen JJ. Metastatic progression of pancreatic cancer: Changes in antioxidant enzymes and cell growth. Clinical and Experimental Metastasis 22:523-532, 200