Medical School:

• University of California at Los Angeles, Los Angeles, CA

Internship:

• University of Michigan Medical Center, Ann Arbor, Michigan

Residency:

• University of Michigan Medical Center, Ann Arbor, Michigan

Fellowships:

• Pediatric Surgery - Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
• Research - NCI Surgical Oncology Research & Clinical Fellow

Certification:

• American Board of Surgery
• Board Certified in Pediatric Surgery

Societies, Organizations, and Honors:

• American Academy of Pediatrics, Fellow
• American College of Surgeons, Fellow
• American Pediatric Surgical Association
• Association of Academic Surgeons
• American Association for the Advancement of Sciences
• American Association of Immunologists
• American Association for Cancer Research
• Society of University Surgeons
• Central Surgical Association

Selected Recent Publications:

• Foglia RP, Shilyansky J, Fonkalsrud EW. Emergency lung biopsy in immunocompromised pediatric patients. Annals of Surgery. 1989.  Vol. 21(1):90-92.
• Shiloni E, Karp SE, Custer MC, Shilyansky J, Restifo NP, Rosenberg SA. Retroviral transformation of interferon-g cDNA into a non-immunogenic MHC Class-I deficient  murine fibrosarcoma: Generation of T-cells capable of treating established parental metastatic tumor. Cancer Immunology and Immunotherapy. 1993. Vol. 37:286-92.
• Kawakami Y, Nishimura MI, Restifo NP, Topalian SL, O’Neil B, Shilyansky J, et al. T-cell recognition of human melanoma antigens. Journal of Immunotherapy. 1993. Vol.  14:88-93.
• Shilyansky J, Nishimura MI, Yang JC, Custer MC, Spiess P, Mule JJ, Rosenberg SA. Murine sarcoma-specific tumor infiltrating lymphocyte (TIL) clone utilizing a unique T-cell receptor rearrangement successfully treats established lung metastases. Surgical Forum. 1993. Vol. 44:521-523.
• Nishimura MI, Kawakami Y, Charmley P, O’Neil B, Shilyansky J, Yannelli JR, et al. T-cell receptor repertoire in tumor infiltrating lymphocytes: Analysis of melanoma specific long term lines. Journal of Immunotherapy. 1994. Vol. 16(2):85-94.
• Shilyansky J, Nishimura MI, Yannelli JR, Kawakami Y, Jacknin LS, Charmley P, et al.  T-cell receptor usage by melanoma specific clonal and highly oligoclonal tumor infiltrating lymphocyte lines. Proceedings of the National Academy of Sciences. 1994.  Vol. 91(7):2829-2833.
• Shilyansky J, Wilson W, Temeck BK, Pass HI. Pulmonary artery-bronchial fistula during lymphoma treatment. Journal of Cardiovascular Surgery. 1994. 108(4):790-91.
• Cole DJ, Weil DP, Shilyansky J, Custer M, Kawakami Y, Rosenberg SA, Nishimura MI. Characterization of the functional specificity of a cloned T-cell receptor heterodimer Recognizing the MART-1 melanoma antigen. Cancer Research. 1995. Vol. 55(4):748-52.
• Shilyansky J, Yang JC, Custer MC, Spiess P, Mixon A, Cole DJ, Mule JJ, Rosenberg SA, and Nishimura MI. Identification of a T-cell receptor from a therapeutic murine T-cell clone. Journal of Immunotherapy. 1997. Vol. 20(4):247-55.
• Metzger S, Goldschmidt N, Barash V, Peretz T, Drize O, Shilyansky J, Shiloni E, Chajek-Shaul T.  Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels. The American Journal of Physiology. 1997. Vol. 273(36):E262-267.
• Shilyansky J, Kreller M, Sena LM, Babyn PS, Pearl RH. Diagnosis and management of duodenal injuries in children. Journal of Pediatric Surgery. 1997. Vol. 32(6):880-891.
• Shilyansky J, Fisher S, Cutz E, Perlman K, Filler RM. Is 95% pancreatectomy the procedure of choice for the treatment of persistent hyperinsulinemic hypolglycemia of the neonate? Journal of Pediatric Surgery. 1997. Vol. 32(2):342-346.
• Shilyansky J, Cutz E, Filler RM. Endogenous hyperinsulinism: Diagnosis, management  and long-term follow-up. Seminars in Pediatric Surgery. 1997. Vol. 6(3):115-120.
• Shilyansky J, Lelli JL Jr., Drongowski RA, Coran AG. Efficacy of the straight endorectal pull-through in the management of familial adenomatous polyposis coli-a 16-year experience. Journal of Pediatric Surgery. 1997. Vol. 32(8):1139-1143.
• Ky A, Shilyansky J, Gerstle JT, Filler RM, Taylor G, Superina RA. Experience with papillary and solid epithelial neoplasms of the pancreas in children. Journal of Pediatric Surgery. 1998. Vol. 33(1):42-44.
• Shilyansky J, Sena L, Kreller M, Chait P, Babyn P, Filler R, Pearl R. Non-operative management of pancreatic injuries in children.  Journal of Pediatric Surgery. 1998. Vol. 33(2):343-349.
• Shilyansky J, Navarro O, Superina RA, Babyn PS, Filler RM, Pearl RH. Delayed hemorrhage after non-operative management for blunt hepatic trauma in children: A rare but significant event. Journal of Pediatric Surgery. 1999. Vol. 34(1):60-64.
• Shilyansky J, Roberts EA, Superina RA. Distal splenorenal shunts for the treatment of severe thrombocytopenia from portal hypertension in children. Journal of Gastrointestinal Surgery. 1999. Vol 3(2):167-172.
• Nicholl M, Shilyansky J, Ota D. Current management of malignant large-bowel obstruction. Contemporary Surgery. 2002. Vol. 58(8):396-400.
• Chen X, Doffek K, Sugg S, Shilyansky J. Neuroblastoma cells inhibit the immunostimulatory function of dendritic cells. Journal of Pediatric Surgery. 2003. Vol. 38(6):901-05.
• Alloo J, Gerstle T, Shilyansky J, Ein SH.  Appendicitis in children less than 3 years of age: A 28-year review. Pediatric Surgery International. 2004. Vol. 19:777-779.
• Nicholl M, Lodge A, Brown I, Sugg S, Shiyansky J. Restored immune response to a MHC-II restricted antigen in tumor bearing Hosts after elimination of regulatory T cells. Journal of Pediatric Surgery. 2004. Vol. 39:941-946.
• Metzger S, Nusair S, Planer D, Barash V, Pappo P, Shilyansky J, Chajek-Shaul T. Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development in mice bearing  IL-1 {beta}-secreting tumor. Endocrinology. 2004. 145(11):5150-5156.
• Nicholl M, Pitt H, Wolf P, Cooney NP, Kalayoglu M, Shilyansky J, Rikkers LF.  Choledochal cysts in western adults: complexities compared to children. Journal of Gastrointestinal Surgery. 2004. Vol. 8(3):245-252.
• Nicholl M, Lodge A, Brown I, Sugg S, Shilyansky J. Restored immune response to an MHC-II-restricted antigen in tumor-bearing hosts after elimination of regulatory T cells. Journal of Pediatric Surgery. 2004. Vol. 39(6); 941-946.
• Chen X, Doffek K, Sugg S, Shilyansky J. Phosphatidylserine modulates the human dendritic cell maturation and function. Journal of Immunology. 2004. Vol. 173:2985-2994.
• Doffek K, Chen X, Gavin C, Sugg S, Shilyansky J.:  PS modulates DC maturation and function by inhibiting ERK1/2, NFkB and p38 MAPK activation in response to LPS.  International Proceedings of Immunology, 2004. 395-400.
• Gavin C, Jacobs P, Doffek K, Shilyansky J.  Phosphatidylserine mediates the inhibitory effects of apoptotic cells on dendritic cells. International Proceedings of Immunology,  2004. 453-459
• Cole D, Weil D, Shilyansky J, Custer M, Kawakami Y, Rosenberg S, Nishimura M.  Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen. Cancer Research, 2005. Vol. 55:748-752.
• Arca M, Somers K, Derks TE, Goldin, AB, Aiken JJ, Sato TT, Shilyansky J, Winthrop A, Oldham KT. Use of vacuum-assisted closure system in the management of complex wounds in the neonate. Pediatric Surgery International, 2005. Vol. 21:532-535.
• Lodge A, Yu P, Nicholl M, Brown I, Jackson C, Schreiber K, Sugg S, Schreiber H, Shilyansky J. CD40 ligation restores cytolytic T lymphocyte (CTL) response and eliminates murine fibrosarcoma in mice lacking CD4+ T cells. Cancer Immunology Immunotherapy. 2006 Dec;55(12):1542-52. Epub 2006 Feb 21.
• Jacobs P, Doffek K, Sugg SL, Shilyansky J. Induction of cytolytic T lymphocytes (CTL) against pediatric solid tumors in vitro using autologous DCs pulsed with necrotic primary tumor. Journal of Pediatric Surgery, 2007 Jan;42(1):54-61; discussion 61.
• Chen X, Doffek K, Gavin C, Orentas R, Johnson B, Matsui K, Sugg SL, Shilyansky J. Phosphatidylserine-dependent suppression of dendritic cell function: a novel mechanism for tumor immune evasion. In preparation.
• Doffek K, Gavin C, Chen X, Sugg SL, Shilyansky J. Phosphatidylserine on the surface of apoptotic cells inhibits NFkB and p38 MAPK activation and induces tolerogenic dendritic cells. In preparation.