Medical School:

• University of Vermont College of Medicine, Burlington, VT

Residency:

• Barnes Hospital/Washington University, St Louis, MO

Fellowship:

• Research Fellow, Washington University, St Louis MO (NCI T32 Surgical Oncology Training Grant)
• Memorial  Sloan-Kettering Cancer Center, New York, NY (Surgical Oncology Clinical Fellowship)

Certification:

• American Board of Surgery 1995

Honors and Awards:

• Mellon Foundation Grant for Independent Research
• Graduation with Distinction in Biology, Dartmouth College
• American Cancer Society, Vermont Division, Summer Fellowship
• American Cancer Society, Vermont Division, Summer Fellowship
• Winner of Surgical Research Prize, University of Vermont College of Medicine
• Research Fellow, NCI T32 Surgical Oncology Training Grant
• Alpha Omega Alpha, Washington University
• Runner-up, Resident's Competition, American Association of Endocrine Surgeons
• Winner, Resident/Fellow's Competition in Basic Science, Society of Surgical Oncology
• American College of Surgeons Owen Wangensteen Faculty Research Fellowship
• Carver Scientist Award, University of Iowa College of Medicine
• Fellow of the American College of Surgeons
• State Chair for Commission on Cancer, Cancer Liaison Program
• Cancer Chairman, Iowa Chapter, American College of Surgeons
• Commission on Cancer
• America’s Top Doctors for Cancer, Castle Connolly Medical Ltd.
• Resident Teacher of the Year Award, Department of Surgery, University of Iowa
• America’s Top Surgeons, Consumer’s Research Council of America
• America’s Top Doctors, Castle Connolly Medical Ltd.

Societies and Organizations:

• Alpha Omega Alpha
• American Association of Endocrine Surgeons
• American Association for the Advancement of Science
• American College of Surgeons
• American College of Surgeons Oncology Group
• American Society of Human Genetics
• American Surgical Association
• Association for Academic Surgery
• Cancer and Leukemia Group B- Clinical Investigator #4898
• Central Surgical Association
• Commission on Cancer
• Iowa Academy of Surgery
• Iowa Medical Society
• Society of Clinical Surgery
• Society of Surgical Oncology
• Society of University Surgeons
• Surgical Biology Club II

Patents:

• "A Gene for Juvenile Polyposis", US Patent Number 6,423,491, awarded July 23, 2002

Selected Recent Publications (Recent Papers):

• Calva, D., O’Dorisio, T.M., O’Dorisio, M.S., Lal, G., Sugg, S., Weigel, R.J., Howe, J.R. (2009) When Is Prophylactic Thyroidectomy Indicated for Patients with the RET C609Y Mutation? Annals of Surgical Oncology 16:2237-2244.
• Barros, R., Mendes, N., Howe, J.R., Reis, C.A., de Bolos, C., Carneiro, F., David, L., Almeida, R. (2009) Juvenile polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4. Histochemistry and Cell Biology 131:765-72.
• Calva, D., Chinnathambi, S., Pechman, B., Bair, J., Larsen Haidle, J., Howe, J.R. (2009) The Rate of Germline Mutations and Larger Deletions of SMAD4 and BMPR1A in Juvenile Polyposis. Clinical Genetics 75:79-85.
• Nishie, A., Obuchi, M, Kuehn, D., Howe, J.R., Dahmoush, L., Stolpen, A. (2008) Small islet cell tumor in the pancreas: diagnostic value of diffusion-weighted imaging. Journal of Medical Imaging and Radiation Oncology 52:374-5.
• Bergmann, O.M., Mathas, M.M., Broadhurst, K.A., Weydert, J.A., Wilkinson, N., Howe, J.R., Haile, D.J., Schmidt, W.N., Brown, K.E. (2008) Altered expression of iron-regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis? Laboratory Investigation 88:1349-57.
• Calva, D., Howe, J.R. (2008) Hamartomatous Polyposis Syndromes. Surgical Clinics of North America 88:779-817.
• Adam, L.A., Smith, B.J., Calva, D., Howe, J.R., Lal, G. (2008) Role for limited neck exploration in young adults with apparently sporadic hyperparathyroidism. World Journal of Surgery 32:1518-24.
• Wilkinson, N.W., Howe, J.R., Gay, G., Patel-Parekh , L., Scott-Conner , C., Donohue, J. (2008) Differences in the Pattern of Presentation and Treatment of Proximal and Distal Gastric Cancer: Results of the 2001 Gastric Patient Care Evaluation. Annals of Surgical Oncology 15:1644-1650.
• Howe, J.R., Chinnathambi, S., Calva, D., Bair, J., Pechman, B., Salamon, A., Tam, B., Simon, L. (2008) A family with consecutive nonsense mutations in BMPR1A causing Juvenile Polyposis. Cancer Genetics and Cytogenetics 181:52-54.
• Lal, G., Padmanabha, L,. Nicholson, R., Smith, B.J., Zhang, L., Howe J.R., Robinson, R.A., O'Dorisio, M.S. (2008) ECM1 expression in thyroid tumors - a comparison of real-time RT-PCR and IHC. Journal of Surgical Research 149:62-8.
• Calva-Cerqueira, D.,Smith, B.J., Hostetler, M.L., Lal, G., Menda, Y., O'Dorisio, T.M., Howe, J.R. (2007) Minimally Invasive Parathyroidectomy and Preoperative MIBI Scans: Correlation of Gland Weight and Preoperative PTH. Journal of the American College of Surgeons 205:S38-44.
• Howe, J.R., Larsen Haidle, J., Lal, G., Bair, J., Song, C., Pechman, B., Chinnathambi, S., Lynch. H.T. (2007) ENG Mutations in MADH4/BMPR1A Mutation Negative Patients with Juvenile Polyposis. Clinical Genetics 71:91-2.
• Lal, G., Padmanabha, L., Smith, B., Nicholson, R., Howe, J.R., O’Dorisio, M.S., Domann, F.E, (2006) RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma. Cancer 107: 2752-9.
• Merg, A., Lynch, H.T., Lynch, J.F., Howe, J.R. (2005) Hereditary Colorectal Cancer. Part I. Current Problems in Surgery 42:185-256.
• Merg, A., Lynch, H.T., Lynch, J.F., Howe, J.R. (2005) Hereditary Colorectal Cancer. Part II. Current Problems in Surgery 42:259-333.
• Tsoulfas, G., Howe, J.R. (2004) Amyand’s Hernia: Appendicitis in an incarcerated inguinal hernia. Surgical Rounds 27:515-517.
• Howe, J.R., Sayed, M.G., Ahmed, A.F., Ringold, J.C., Larsen-Haidle, J., Merg, A., Mitros, F.A., Vaccaro, C.A., Petersen, G.M. Giardiello, F.M., Tinley, S.T., Aaltonen, L.A., Lynch, H.T. (2004) The Prevalence of SMAD4 and BMPR1A Mutations in Juvenile Polyposis, and Absence of Mutations of BMPR2, BMPR1B, and ACVR1. Journal of Medical Genetics 41:484-491.
• Merg, A., Howe, J.R. (2004) Genetic conditions associated with intestinal juvenile polyps. American Journal of Medical Genetics Part C (Seminars in Medical Genetics) 129C:44-55.
• Lynch, H.T. Tinley, S.T., Shaw, T.G., Lynch, J.F., Howe, J.R., Attard, T.M. (2004) Challenging polyposis pedigrees: Differential diagnosis, surveillance, and management concerns. Cytogenetics and Cell Genetics 148:104-117.
• McCarthy, D.M., Hruban, R.H., Argani, P., Howe, J.R., Conlon, K.C., Brennan, M.F., Zahurak, M. Wilentz, R.E., Cameron, J.L., Yeo, C.J., Kern, S.E., Klimstra, D.S. (2003) The role of DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: Analysis of 140 cases. Modern Pathology 16:272-278.

Recent Book Chapters:

• Howe, J.R. Laparoscopic adrenalectomy. (2009) In Operative Anatomy, 3rd Ed. (C.E.H. Scott-Conner, D.L. Dawson, eds.), pp. 614-18, Wolter Kluwer/ Lippincott Williams & Wilkins, Philadelphia.
• Howe, J.R. Laparoscopic adrenalectomy. (2003) In Operative Anatomy, 2nd Ed. (C.E.H. Scott-Conner, D.L. Dawson, eds.), pp. 535-539, J.B. Lippincott, Philadelphia.
• Howe, J.R. MEN Syndromes. (2003) In Surgical Oncology: An algorithmic approach (T.J., Saclarides, K.W., Millikan, and C.V. Godellas, eds.), pp. 138-151, Springer-Verlag, New York.
• Howe, J.R. Juvenile Polyposis Syndrome. (2002) In The Genetic Basis of Human Cancer, 2nd Edition (B. Vogelstein, K.W. Kinzler, eds.), pp. 343-356, McGraw-Hill, New York
• Howe, J.R. Molecular Markers as a Tool for the Early Diagnosis of Pancreatic Cancer. (2002) In M.D. Anderson Solid Tumor Series: Pancreatic Cancer (D.B. Evans, P.W. Pisters, J.L. Abbruzzese, eds.), pp. 29-46. Springer-Verlag, New York.
• Howe, J.R. Juvenile Polyposis Syndrome. (2001) In The Metabolic and Molecular Bases of Inherited Disease, 8th Edition (C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle, B. Childs, B. Vogelstein eds.), pp. 805-818. McGraw-Hill, New York.
• Wright, N.A, Howe, J.R., Rossini, F.P., Shepherd, N.A., Pennazio, M., Sobin, L.H., Carr, N.J., Talbot, I. (2000) Tumours of the Small Intestine. In WHO Classification of Tumours, Vol. II: Pathology and Genetics of Tumours of the Digestive System (S. Hamilton and L.A. Aaltonen, eds.), pp. 71-74. International Agency for Research on Cancer, Lyon.
• Aaltonen, L.A, Jass, J.R., Howe, J.R. (2000) Juvenile Polyposis. In WHO Classification of Tumours, Vol. II: Pathology and Genetics of Tumours of the Digestive System (S. Hamilton and L.A. Aaltonen, eds.), pp. 130-132. International Agency for Research on Cancer, Lyon.
• Howe, J.R., and Wells, S.A., Jr. (1995) Surgery for diseases of the parathyroid glands. In Atlas of Surgical Oncology (C.P. Karakousis, E.M. Copeland, and K.I. Bland, eds.), pp. 145-150. W.B. Saunders, Philadelphia.
• Howe, J.R., and Wells, S.A., Jr. (1992) Recurrent and persistent hyperparathyroidism. In Current Surgical Therapy (J. Cameron, ed.), Fourth Edition, pp.583-590. B.C. Decker, St. Louis.