Medical School:

• University of Vermont College of Medicine, Burlington, VT

Residency:

• Barnes Hospital/Washington University, St Louis, MO

Fellowship:

• Research Fellow, Washington University, St Louis MO (NCI Surgical Oncology Training Grant)
• Memorial  Sloan-Kettering Cancer Center, New York, NY (Surgical Oncology Clinical Fellowship)

Certification:

• American Board of Surgery 1995

Honors and Awards:

• Mellon Foundation Grant for Independent Research
• Graduation with Distinction in Biology, Dartmouth College
• American Cancer Society, Vermont Division, Summer Fellowship
• American Cancer Society, Vermont Division, Summer Fellowship
• Winner of Surgical Research Prize, University of Vermont College of Medicine
• Research Fellow, NCI T32 Surgical Oncology Training Grant
• Alpha Omega Alpha, Washington University
• Runner-up, Resident's Competition, American Association of Endocrine Surgeons
• Winner, Resident/Fellow's Competition in Basic Science, Society of Surgical Oncology
• American College of Surgeons Owen Wangensteen Faculty Research Fellowship
• Carver Scientist Award, University of Iowa College of Medicine
• Fellow of the American College of Surgeons

Societies and Organizations:

• Alpha Omega Alpha
• American Association of Endocrine Surgeons
• American College of Surgeons
• American Society of Human Genetics
• Association for Academic Surgery
• Cancer and Leukemia Group B- Clinical Investigator #4898
• Iowa Academy of Surgery
• Iowa Medical Society
• Society of Surgical Oncology
• Society of University Surgeons  

Patents:

• "A Gene for Juvenile Polyposis", Number EL259185248US, deposited May 13, 1999 (pending)
• "BMPR1A Involvement in Juvenile Polyposis", provisional application deposited May 21, 2001 (pending).

Selected Recent Publications (Recent Papers):

• Howe, J.R., Klimstra, D.S., Cordon-Cardo, C., Paty, P.P., Park. P., Brennan, M.F. (1997) K-ras mutation in adenomas and carcinomas of the ampulla of Vater. Clinical Cancer Research 3:129-133.
• Howe, J.R., Guillem, J.G. (1997) The genetics of colorectal cancer. Surgical Clinics of North America 77:175-196
• Howe, J.R., Conlon, K. (1997) The molecular genetics of pancreatic cancer. Surgical Oncology 6:1-18.
• Howe, J.R., Klimstra, D.S., Cordon-Cardo, C. (1997) DNA extraction from paraffin embedded tissues using a salting out procedure: A reliable method for PCR amplification of archival material. Histology and Histopathology 12:595-601.
• Howe, J.R., Ringold, J.C., Summers, R.W., Mitros, F.A., Nishimura, D.Y., Stone, E.M. (1998) A gene for familial juvenile polyposis maps to chromosome 18q21.1. American Journal of Human Genetics 62:1129-1136.
• Howe, J.R., Roth, S., Ringold, J.C., Summers, R.W., Jarvinen, H.J., Sistonen, P., Tomlinson, I.P.M., Houlston, R., Bevan, S., Mitros, F.A., Stone, E.M., Aaltonen, L.A. (1998) Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 280:1086-1088.
• Howe, J.R., Klimstra, D.S., Moccia, R.D., Conlon, K.C., Brennan, M.F. (1998) Factors predictive of survival in ampullary carcinoma. Annals of Surgery 228:87-94.
• Howe, J.R., Ringold, J.C., Mitros, F.A, Summers, R.W. (1998) Presymptomatic diagnosis of gene carriers in familial juvenile polyposis. Surgical Forum 49:142-144.
• Howe, J.R., Mitros, F.A., Summers, R.W. (1998) The risk of gastrointestinal cancer in familial juvenile polyposis. Annals of Surgical Oncology 5:751-756.
• Howe, J.R., Ringold, J.C., Hughes, J.A., Summers, R.W. (1999) Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis. Surgery 126:162-170.
• Howe, J.R. (1999) A new pathway for the development of colorectal cancer: Lessons learned from Juvenile Polyposis. Cancer Research Alert 1:8-9.
• Howe, J.R., Karnell, L.H., Menck, H.R., Scott-Conner, C. (1999) Adenocarcinoma of the small bowel: Prognostic factors from the National Cancer Data Base. Cancer 86:2693-2706.
• Howe, J.R. (2000) Minimally invasive parathyroidectomy. Surgical Clinics of North America 80:1399-1426.
• Howe, J.R., Bair, J.A., Sayed, M.G., Anderson, M.E., Mitros, F.A., Petersen, G.M., Velculescu, V. E., Traverso, G., Vogelstein, B. (2001) Germline mutations of the gene for bone morphogenetic protein receptor 1A in juvenile polyposis. Nature Genetics 28:184-187.
• Howe, J.R., Karnell, L.H., Scott-Conner, C. (2001) Small Bowel Sarcoma: Analysis of survival from the National Cancer Data Base. Annals of Surgical Oncology 8:496-508.
• Sayed, M.G., Bair, J.L., Anderson, M.E., Riggins, G.J., Petersen, G.M., Mitros, F.A., Summers, R.W., Lynch, H.T., Giardiello, F.M., Vogelstein, B., Howe, J.R. The Frequency of SMAD4 and PTEN Mutations in Juvenile Polyposis. (2001) Surgical Forum 52:230-231.
• Costa, J.A., Kreder, K.J., Howe, J.R. Combined urinary and fecal diversion using a 'no anastomosis' technique. The Journal of Urology (in press).
• Howe, J.R., Wagner, B., Shellnut,, J., Ringold, J., Sayed, M.G., Ahmed, A.F., Lynch, P.M., Amos, C.I., Sistonen, P., Aaltonen, L.A. Common Deletion of SMAD4 in Juvenile Polyposis is a Mutational Hotspot (submitted).

Recent Book Chapters:

• Aaltonen, L.A, Jass, J.R., Howe, J.R. (2000) Juvenile Polyposis. In WHO Classification of Tumours, Vol. II: Pathology and Genetics of Tumours of the Digestive System (S. Hamilton and L.A. Aaltonen, eds.), pp. 130-132. International Agency for Research on Cancer, Lyon.
• Wright, N.A, Howe, J.R., Rossini, F.P., Shepherd, N.A., Pennazio, M., Sobin, L.H., Carr, N.J., Talbot, I. (2000) Tumours of the Small Intestine. In WHO Classification of Tumours, Vol. II: Pathology and Genetics of Tumours of the Digestive System (S. Hamilton and L.A. Aaltonen, eds.), pp. 71-74. International Agency for Research on Cancer, Lyon.
• Howe, J.R. Juvenile Polyposis Syndrome. (2001) In The Metabolic and Molecular Bases of Inherited Disease, 8th Edition (C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle, B. Childs, B. Vogelstein eds.), pp. 805-818. McGraw-Hill, New York.
• Howe, J.R. Molecular Markers as a Tool for the Early Diagnosis of Pancreatic Cancer. (2002) In MD Anderson Solid Tumor Series: Pancreatic Cancer (D.B. Evans, P.W. Pisters, J.L. Abbruzzese, eds.), pp. 29-46. Springer-Verlag, New York.
• Howe, J.R. MEN Syndromes. In Surgical Oncology: An algorithmic approach (T.J., Saclarides, K.W., Millikan, and C.V. Godellas, eds.) Springer-Verlag, New York (in press).
• Howe, J.R. Juvenile Polyposis Syndrome. In The Genetic Basis of Human Cancer, 2nd Edition (B. Vogelstein, K.W. Kinzler, eds.) McGraw-Hill, New York (in press).
• Howe, J.R. Laparoscopic adrenalectomy. In Operative Anatomy, 2nd Ed. (C.E.H. Scott-Conner, D.L. Dawson, eds.) J.B. Lippincott, Philadelphia (in press).