Peg Nopoulos, MD
Program Director
Education:
- BS, University of Iowa, 1985
- MD, University of Iowa, 1989
Professional Experience:
- Residency in the Department of Psychiatry at The University of Iowa Hospitals and Clinics, Iowa City, IA1989-1993
- Postdoctoral fellow, Neuropsychiatry, Department of Psychiatry, The University of Iowa Hospitals and Clinics, 1992-1994
- Fellow Associate, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA, 1993
- Assistant Professor, Department of Psychiatry, The University of Iowa College of Medicine, 1994-2000
- Associate Professor, Department of Psychiatry, The University of Iowa College of Medicine, 2000-2005
- Professor, Department of Psychiatry, The University of Iowa College of Medicine, 2005 - present
Honors & Awards
- Teacher of the Year, 1995
- Young Scientist Award, Eighth Biennial Winter Workshop on Schizophrenia, 1996
- Kempf Fund Award for Research Development in Psychobiological Psychiatry, 1996
- Mead Johnson/American College of Neuropsychopharmacology Travel Award, 1996
- Young Investigator Award, International Congress on Schizophrenia Research, 1997
- Nominated "Teacher of the Year" by the fourth year medical students, 2000
- Nominated “Outstanding Teacher” by the second year medical students, 2000-2001
- Teacher of the Year, Department of Psychiatry, 2001
- Nominated "College of Medicine Faculty Service Award", 2001
- 14th Annual Nancy C.A. Roeske, MD, Certificate of Recognition for Excellence in Medical Student Education, American Psychiatry Association, 2004
Selected Publications
- Nopoulos, P., M. Flaum, D. Miller: Atypical neuroleptic malignant syndrome with an atypical neuroleptic. Annals of Clinical Psychiatry 2(4):251-253, 1990.
- Nopoulos, P., L. Flashman, M. Flaum, S. Arndt, and N.C. Andreasen. Stability of cognitive functioning early in the course of schizophrenia. Schizophrenia Research 14:29-37, 1994.
- Andreasen N.C., S.A. Arndt, D.S. O'Leary, M. Flaum, and P. Nopoulos. Clinical presentation and cognitive dysfunction in schizophrenia. International Academy for Biomedical and Drug Research (10):1-8, 1995.
- Arndt, S., N.C. Andreasen, M. Flaum, D. Miller, and P. Nopoulos. A longitudinal study of symptom dimensions in schizophrenia: Prediction and patterns of change. Archives of General Psychiatry 52:352-360, 1995.
- Nopoulos, P., I. Torres, M. Flaum, N.C. Andreasen, J.C. Ehrhardt, & W.T.C. Yuh. Brain morphology in first episode schizophrenia. American Journal of Psychiatry 152:1721-1723, 1995.
- Nopoulos, P., M. Flaum, N.C. Andreasen, and V.W. Swayze. Gray matter hetertopias in schizophrenia. Psychiatry Research: Neuroimaging 61:11-14, 1995.
- Andreasen N.C., D.S. O'Leary, S. Arndt, T. Cizadlo, P. Nopoulos, and M. Flaum. Neural substrates of frontal function in schizophrenia. In Dopamine Disease States, R.J. Beninger, T. Palomo, and T. Archer, ed. 1996.
- Nopoulos, P., S. Schultz, and N.C. Andreasen. Brain and behavior. In Textbook of Women's Health, L. Wallis, ed. Little Brown and Company, 1996.
- Nopoulos, P., V. Swayze, N.C. Andreasen: Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi. Journal of Neuropsychiatry and Clinical Neurosciences 8(2):147-152, 1996.
- Andreasen, N.C., D.S. O'Leary, M. Flaum, P. Nopoulos, G.L. Watkins, L.L.B. Ponto, and R. Hichwa. Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients. Lancet (349):1730-1734, 1997.
- Andreasen, N.C., D.S. O'Leary, M. Flaum, P. Nopoulos, G.L. Watkins, L.L.B. Ponto, and R.D. Hichwa. Circuits in neuroleptic naive patients. Lancet (349):1730-1734, 1997.
- Flaum M., P. Nopoulos, S. Arndt, T. Cizadlo, and N. Andreasen. An MRI study of grey matter, white matter, and cerebral spinal fluid volumes in patients with schizophrenia vs. normal controls. NeuroImage (5):277, 1997.
- Nopoulos, P., V.W. Swayze, M. Flaum, W.T.C. Yuh, J.C. Ehrhardt, S.V. Arndt, and N.C. Andreasen. Cavum septi pellucidi in normals and patients with schizophrenia as detected by MRI. Biological Psychiatry (41):1002-1008, 1997.
- Nopoulos, P., M. Flaum, and N.C. Andreasen. Sex differences in brain morphology. American Journal of Psychiatry, (154)12:1648-1654, 1997.
- Nopoulos, P., J. Giedd, J. Rapoport, and N.C. Andreasen. Incidence and severity of enlarged cavum septi pellucidi in childhood onset schizophrenia, American Journal of Psychiatry 155:1074-1079, 1998.
- Nopoulos, P., M. Flaum, S. Arndt, and N.C. Andreasen: Morphometry in schizophrenia revisited: Height and its relationship to premorbid functioning, Psychological Medicine 28:655-663, 1998.
- Nopoulos, P., V.W. Swayze, M. Flaum, and N.C. Andreasen. Incidence of ectopic gray matter in patients with schizophrenia and healthy controls using MRI. J Neuropsychiatry and Clinical Neuroscience 10:351-353, 1998.
- Tibbo, P., P. Nopoulos, S. Arndt, and N.C. Andreasen. Corpus callosum shape and size morphology in male patients with schizophrenia, Biological Psychiatry 44:405-412, 1998.
- Andreasen N., P. Nopoulos, D. O'Leary, D. Miller, T. Wassink, and M. Flaum. Defining the phenotype of schizophrenia: Cognitive dysmetria and its neural mechanisms. Biol Psych 46:908-920, 1999.
- Corson P., P. Nopoulos, N. Andreasen, D. Heckel, and S. Arndt. Caudate size in first episode neuroleptic-naive schizophrenic patients measured using an artificial neural network. Biol Psych 46:712-720, 1999.
- Corson, P.W., P Nopoulos, D Miller, S. Arndt, and N. Andreasen. Change in basal ganglia volume over 2 years in patients with schizophrenia: Typical vs. atypical neuroleptics. AJP 156:1200-1204, 1999.
- Gold, S., S. Arndt, P. Nopoulos, D. O'Leary, and N.C. Andreasen. Longitudinal study of cognitive function in first episode and recent onset schizophrenia. American Journal of Psychiatry 156:1342-1348, 1999.
- Ho BC, Miller D, Nopoulos P, Andreasen NC. A comparative effectiveness study of risperidone and olanzapine in the treatment of schizophrenia, J Clin Psychiatry 60:658-663, 1999.
- Magnotta, V., N.C. Andreasen, G. Harris, T. Cizadlo, P. Nopoulos, S. Schultz, and M. Flaum. Quantitative in vivo measurement of gyrification in the human brain. Cerebral Cortex 9:151-160, 1999.
- Nopoulos P., J. Ceilley, E. Gailis, and N. Andreasen. An MRI study of cerebellar vermis morphology in patients with schizophrenia: Evidence in support of the cognitive dysmetria concept. Biol Psych 46:703-711, 1999.
- Nopoulos, P. Gender Differences in Neuroimaging, in American Psychiatric Press Review of Psychiatry: “Gender Differences in Mood and Anxiety Disorders: From Bench to Bedside” Leibenluft, M.D. editor. Washington, D.C., American Psychiatric Press, 1999 pp1-30.
- Wassink, T., N. Andreasen, P. Nopoulos, and M. Flaum. Cerebellar morphology as a predictor of symptom and psychosocial outcome in schizophrenia. Biol Psychiatry 45:41-48, 1999.
- Wassink, T.H., M. Flaum, P. Nopoulos, and N.C. Andreasen. Prevalence of depressive symptoms early in the course of schizophrenia. American Journal of Psychiatry 156:315-316, 1999.
- Ho, B-C., N.C. Andreasen, M. Flaum, P. Nopoulos, D. Miller. Untreated initial psychosis: Its relation to quality of life and symptom remission in first-episode schizophrenia. Am J Psychiatry 157:808-815, 2000.
- Nopoulos, P., S. Berg, F.X. Castellenos, A. Delgado, N.C. Andreasen, and J.L. Rapoport. Developmental brain anomalies in children with attention deficit hyperactivity disorder. Journal of Child Neurology 15:102-108, 2000
- Nopoulos P., M. Flaum, D. O'Leary, and N.C. Andreasen. Sexual dimorphism in the human brain: evaluation of tissue volume, tissue composition and surface anatomy using magnetic resonance imaging. Psych Res 98:1-13, 2000.
- Nopoulos, P., S. Berg, J. Canady, L. Richman, D. Van DeMark, N.C. Andreasen. Abnormal brain morphology in patients with isolated cleft lip and/or palate: a preliminary analysis. Cleft Palate Craniofac J 37:441-446, 2000
- Nopoulos, P., Krie, A., Andreasen, N.C. Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlates. J Neuropsychiatry Clin Neurosci 12:344-49, 2000
- Nopoulos, P., Rideout, D., Crespo-Facorro, B., Andreasen, N.C. Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls. Schizophr Res 48:177-185, 2001
- Nopoulos, P., Ceilley, J. Gailis, E., Andreasen, N.C. An MRI study of midbrain morphology in patients with schizophrenia: relationship to psychosis, neuroleptics, and cerebellar neural circuitry. Biol Psychiatry 49:13-19, 2001.
- Nopoulos, P., D. Miller, M. Flaum, & N. Andreasen. Issues in the assessment of negative symptom treatment response. In R. Keefe, J. McEvoy, eds, Assessment of Negative Symptom Treatment Response, AJP Press pp 19-32, 2001.
- Schultz SK, Nopoulos PC, Andreasen NC: Neuroanatomy: A Regional Understanding, in Current Issues in the Psychopharmacology of Schizophrenia, Breier A, Tran PV, Herrera J, Bymaster F, Tollefson (eds), Williams and Wilkens, Baltimore, 2001, pp 12-26.
- Nopoulos P, Berg S, Canady J, Richman L, Van DeMark D, Andreasen NC. Increased incidence of a midline brain anomaly in subjects with non-syndromic clefts of the lip and/or palate. J Neuroimaging 2001; 4:418-424.
- Nopoulos P, Berg S, Canady J, Richman L, VanDemark D, Andreasen NC. Structural brain abnormalities in adult males with clefts of the lip and/or palate. Genet Med 2002; 4:1-9.
- White T, Andreasen NC, Nopoulos P. Brain volumes and surface morphology in monozygotic twins. Cereb Cortex 2002; 12:486-493.
- Fuller R, Nopoulos P, Arndt S, O’Leary D, Ho BC, Andreasen NC. Longitudinal assessment of pre-morbid cognitive functioning in schizophrenia using the Iowa Test of Basic Skills/ Iowa Test of Educational Development. Am J Psychiatry 2001; 159:1183-1189.
- Nopoulos P, Berg S, Van DeMark D, Richman L, Canady J, Andreasen NC. Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate. Neuropsychological 2002; 40:2178-2184.
- Andreasen NC, White T, Nopoulos P. Novel methods to study brain morphology in schizophrenia. European Psychiatry: the Journal of the Association of European Psychiatrists 2002; 17(1):86-87.
- Wassink TH, Nopoulos P, Pietila J, Crowe RR, Andreasen NC. NOTCH4 and the frontal lobe in schizophrenia. Am J Med Genet 2003; 118B(1):1-7.
- White T, Andreasen NC, Nopoulos P, Magnotta V. Gyrification abnormalities in childhood- and adolescent-onset schizophrenia. Biol Psychiatry 2003; 54:418-426.
- Ho, BC., Andreasen, N.C., Nopoulos, P., Arndt, S., Magnotta, V., Flaum, M. Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal MRI study early in the course of schizophrenia. Arch Gen Psychiatry, 2004; 60 (6):585-594.
- Beglinger, L., Nopoulos, P., Jorge, R., Langbehn, D., Mikos, A., Moser, D., Duff, K., Robinson, R., Paulsen, J. White matter volume and cognitive dysfunction in early huntington’s disease. Cognitive and Behavioral Neruology, 2005, 18 (1).
- Gallin, E.K., Le Blanc1, S.M., and Clinical Research Fellowship Program Directors. Launching a New Fellowship for Medical Students: The First Years of the Doris Duke Clinical Research Fellowship Program. Journal of Investigative Medicine, 2005, 53 (2): 73-81.
- Nopoulos P, Choe I, Berg S, Van demark D, Canady J, Richman L. Ventral frontal cortex morphology in adult males with isolated orofacial clefts: relationship to abnormalities in social function. Cleft Palate Craniofac J, 2005, 42 (2): 138-144.
- Pressler, M., Nopoulos, P., Ho, B.C., Kim, JJ., Chemerinski, E., Magnotta, V., Crespo-Facorro, B., Andreasen, N.C. Insular cortex abnormalities in schizophrenia: relationship to symptoms and typical neuroleptic exposure, Biol Psychiatry. Accepted for publication.