P&T News: March 1997: The Recommended Childhood Vaccination Schedule: Update on Recent Changes
Joan M. Murhammer, R.Ph., Clinical Pharmacist
Peer Review Status: Internally Peer Reviewed by Ellen A.
Link, M.D., Clinical Assistant Professor, Department of Pediatrics
and Jody R. Murph, M.D., Associate Professor, Department of
Pediatrics
|
Vaccination |
Brand Name/Formulary Status(2) |
Dose |
Route |
Age Range |
Recommended |
|
Hepatitis B |
Engerix[R]-B |
10 mcg/0.5 ml |
IM |
0 to 9 yrs |
0, 1, 6 mos |
|
20 mcg/ 1 ml |
IM |
20 or more yrs |
0, 1, 6 mos | ||
|
Recombivax[R]HB |
2.5 mcg/0.5 ml |
IM |
0 to 10 yrs |
HBsAG(-) mother; 0, 1, 6 mos starting at birth or 2 mos | |
|
5 mcg/0.5 ml |
IM |
0 to 10 yrs |
HBsAG(+) mother; 0, 1, 6 mos starting at birth or 2 mos | ||
|
5 mcg/0.5 ml |
IM |
11 to 19 yrs |
0, 1, 6 mos | ||
|
10 mcg/1 ml |
IM |
20 or more yrs |
0, 1, 6 mos | ||
|
Diphtheria, Tetanus, & Acellular Pertussis |
Infanrix[R], Acel-Imune[R], Tripedia[R] |
0.5 ml |
IM |
6 wks up to 7 yrs |
2,4,6,15 to 18 mos, and 4 to 6 yrs (5 doses) |
|
Diphtheria, Tetanus, & Pertussis |
Connaught |
0.5 ml |
IM |
6 wks up to 7 yrs |
2,4,6,15 to 18 mos, and 4 to 6 yrs (5 doses) |
|
Haemophilus B Conjugate (Hib)(4) |
HibTITER[R] (HbOC), ActHIB[R]/OmniHIB[R] (PRP-T) |
0.5 ml |
IM |
6 wks up to 5 yrs |
2,4,6,12 to 15 mos (4 doses) |
|
Pedvax[R] HIB (PRP-OMP) |
0.5 ml |
IM |
6 wks up to 5 yrs |
2,4,12 to 15 mos (3 doses) | |
|
ProHIBIT[R] (PRP-D) |
0.5 ml |
IM |
18 mos to 5 yrs |
Only approved for use as a booster dose | |
|
Polio(5) |
Orimune[R] |
0.5 ml |
PO |
6 or more wks |
2,4,6 to 18 mos, and 4 to 6 yrs (4 doses) OR 2 doses at 12 to 18 mos and 4 to 6 yrs after receiving 2 doses of IPV at 2 and 4 mos |
|
IPOL[R], Poliovax[R] |
0.5 ml |
SQ |
6 or more wks |
2,4,12 to 18 mos and 4 to 6 yrs (4 doses) OR 2 doses at 2 and 4 mos followed by 2 doses of OPV at 12 to 18 mos and 4 to 6 yrs | |
|
Measles, Mumps, and & Rubella |
M-M-R II[R] |
0.5 ml |
SQ |
12 or more mos |
12 to 15 mos and either 4 to 6 yrs or 11 to 12 yrs (2 doses) |
|
Varicella |
Varivax[R] |
0.5 ml |
SQ |
12 or more mos |
12 to 18 mos (1 dose) If not given at 12 to 18 mos, 1 dose for ages 1 to 12 yrs and 2 doses given 4 to 8 wks apart if 13 yrs or older |
|
Hepatitis A |
Havrix[R] |
360 EL.U/0.5ml[6] |
IM |
2 to 18 yrs |
0,1,6 to 12 mos (3 doses) |
|
720 EL.U/0.5ml[6] |
IM |
2 to 18 yrs |
0,6 to 12 mos (2 doses) | ||
|
1440 EL.U/1 ml |
IM |
more than 18 yrs |
0,6 to 12 mos (2 doses) | ||
|
Vaqta[R] |
25 U/0.5 ml |
IM |
2 to 17 yrs |
0,6 to 18 mos (2 doses) | |
|
50 U/1 ml |
IM |
more than 17 yrs |
0,6 mos (2 doses) | ||
|
Hepatitis B & Haemophilus b Conjugate (PRP-OMP)(7) |
Comvax[R] |
0.5 ml |
IM |
6 or more wks |
2,4,12 to 15 mos (3 doses) |
|
Diphtheria, Tetanus, Pertussis, & Haemophilus b Conjugate (HbOC) |
Tetramune[R] |
0.5 ml |
IM |
6 wks up to 7 yrs |
2,4,6 and 15 to 18 mos (4 doses) and an additional dose of DTP/DTaP needs to be administered at 4 to 6 yrs |
|
Diphtheria, Tetanus, Acellular Pertussis, & Haemophilus b Conjugate (PRP-T) |
TriHIBIT[R] |
0.5 ml |
IM |
15 mos to 5 yrs |
15 to 18 mos (not approved for the primary 3 doses) and an additional dose of DTP/DTaP needs to be administered at 4 to 6 yrs |
1. These are general administration guidelines for children who start the vaccine schedule at the appropriate age. See the 1994 Red Book for guidelines on accelerated schedules and for contraindications and precautions to the agents' uses.
2. Bold print designates vaccines available on the UIHC Formulary.
3. DTaP is the preferred agent for all doses in the pertussis series.
4. The number of doses required depends on the age of the patient and the product used.
5. Sequential IPV/OPV is the preferred regimen.
6. Those who receive an initial dose of 360 EL.U or 720 EL. U should continue on that dosing schedule. Individuals should not alternate between the two strengths. Please note, the 360 EL.U strength is not currently available on the UIHC Formulary.
7. Babies born to HBsAG(+) mothers may receive 3 doses of Comvax[R], but require hepatitis B vaccine and hepatitis B immune globulin at birth.
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