Microbiology/Molecular Pathology
Molecular Pathology Contact Information:
| Aaron Bossler, MD, PhD MGP board certified Director, Molecular Pathology 319-384-9566 aaron-bossler@uiowa.edu |
Connie Floerchinger, MS, MHA Laboratory Manager 319-384-9867 connie-floerchinger@uiowa.edu |
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| Jonathan W. Heusel, MD, PhD MGP board certified Director, Molecular Oncology Testing 319-335-8217 jon-heusel@uiowa.edu |
Deqin Ma, MD, PhD Faculty 319-394-5700 deqin-ma@uiowa.edu |
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Advances in molecular biology and biomedical research have had a major impact on the practice of clinical medicine. Sequencing of the human genome has aided in the discovery of many new disease-associated genes. In addition, technological advances have permitted the identification of the molecular mechanisms of numerous diseases.
Molecular pathology is the application of the principles, theory, and technologies of molecular biology and molecular genetics to questions and problems in clinical medicine. Applications of molecular pathology abound in the practice of both clinical and anatomic pathology.
Molecular pathology is used to:
- Help make rapid and accurate diagnoses. (Surgical Pathology)
- Detect and monitor infectious agents. (Microbiology)
- Establish clonality, particularly for lymphoid diseases. (Hematopathology)
- Assess the presence of minimal residual disease for some malignancies after therapy.
- Determine prognosis and/or predict response to therapy.
- Perform testing for inherited diseases.
The Molecular Pathology Laboratory at the University of Iowa Hospitals and Clinics is committed to the development of clinical molecular testing for the benefit of our patients and the advancement of the field. The Molecular Pathology Laboratory provides testing and consultation in all areas of molecular diagnostics including genetics, infectious disease and oncology testing. The laboratory places emphasis on testing in the area of neuromuscular diseases, epigenetic conditions and molecular virology testing.
The current list of testing performed by the laboratory is listed below with links to the University of Iowa Diagnostic Laboratories (UIDL) Test Directory Handbook. The UIDL operates the Reference Laboratory/Outreach Client Services for clinical and anatomic pathology testing and consultation. The Molecular Pathology Requisitions for UIDL requests for testing can be found within each test entry. Requests for University of Iowa Hospitals and Clinics (UIHC) in-house testing can be obtained through the Laboratory Services Handbook.
Fellowship Training
The Department of Pathology offers subspecialty training in molecular genetic pathology and clinical microbiology. The subspecialty of molecular genetic pathology arose in parallel with the growth in knowledge about the molecular basis of diseases and the technological advances which made molecular diagnosis in the clinical laboratory possible. The Molecular Genetic Pathology (MGP) Fellowship Program at Iowa has received provisional accreditation.
Click here for information on the Molecular Genetic Pathology Fellowship Program
Click here for information on the Clinical Microbiology Fellowship Program
• Association for Molecular Pathology
• GeneTests
Test Menu [NOTE: Links for the following tests are to the University of Iowa Diagnostic Laboratories (UIDL) Test Directory for outreach clients. Please refer to the Laboratory Services Handbook for information regarding testing within the University of Iowa Hospitals and Clinics.]
Genetics Testing
Angelman Syndrome
Calpain 3 Sequencing
Facioscapulohumeral Dystrophy (FSHD)
Facioscapulohumeral Dystrophy (FSHD), Prenatal
Factor 5 Leiden/Factor 2 Gene PCR Assay
FCMD Japanese Founder Mutation (PCR)
FKRP Sequencing
Fragile X, DNA Testing
Fukutin Gene Sequencing
Hemochromatosis, DNA Testing
Huntington Disease, DNA Testing
Lamin A/C Sequencing
Limb Girdle Muscular Dystrophy (Autosomal Recessive Panel and FKRP Sequencing)
Limb Girdle Muscular Dystrophy, Autosomal Recessive (LGPCR) - Mutation Analysis
Myotonic Dystrophy (Type 1), DNA Testing
POMT1 Sequencing
POMT2 Sequencing
POMGNT1 Sequencing
Prader-Willi Syndrome
Transforming Growth Factor Beta Receptor 2 (exon 5, R460C)
Infectious Disease Testing
Chlamydia trachomatis Detection by PCR
Cytomegalovirus (CMV) Quantitation by PCR
Enterovirus Qualitative PCR Assay
Hepatitis C Genotype
Hepatitis C Virus RNA
Herpes Simplex Encephalitis by PCR
HIV Viral Load by PCR
Human Papillomavirus (HPV) High Risk
Human Papilloma Virus
Neisseria gonorrhoeae Detection by PCR
VanA/VanB Detection by PCR (rule out VRE)
Oncology Testing
bcl-2 PCR Assay for Lymphoma
BRAF Mutation Analysis
Epidermal Growth Factor Receptor (EGFR) Sequencing
FLT3&NPMI Mutation Detection
IGH Gene Clonality by PCR
JAK2 V617F Mutation Detection Assay
KRAS Mutational Analysis
Microsatellite Instability
TCRG Clonality by PCR