Research
Laboratory Experimental Biology of Prostate Cancer
Michael B. Cohen, M.D.
Professor and Head of Pathology
Richard G. Lynch Chair in Experimental Pathology
Laboratory: 1132 ML
Office: 319-384-9609
Laboratory Phone: 319-335-8188
Email: michael-cohen@uiowa.edu
PUBLICATIONS - (See complete publications list at PubMed)
Rokhlin OW, Guseva NV, Taghiyev AG, Glover RA, Cohen MB. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther, 9:223-234, 2010.
Cohen MB, Rokhlin OW. Mechanisms of prostate cancer cell survival after inhibition of AR expression. J Cell Biochem 106:363-71, 2009.
Rokhlin OW, Scheinke VS, Taghiyev AF, Bumcrot D, Glover RA, Cohen MB. MicroRNA-34 mediates AR-dependent p53-induced apoptosis in prostate cancer. Cancer Biol Ther 7:1288-96, 2008.
Rokhlin OW, Taghiyev AF, Bayer UK, Bumcrot D, Koteliansky VE, Glover RA, Cohen MB. Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival. Cancer Biol Ther 6:732-42, 2007.
Rokhlin OW, Glover RB, Guseva NV, Taghiyev AF, Kohlgraf KG, Cohen MB. Mechanisms of cell death induced by histone deacetylase inhibitors in androgen receptor-positive prostate cancer cells. Mol Cancer Res. 4:113-23, 2006.
Rokhlin OW, Taghiyev AF, Guseva NV, Glover RA, Chumakov PM, Kravchenko JE, Cohen MB. Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP. Oncogene 24:6773-84, 2005.
GRANTS
| Sponsor (Status) | Number | Project |
| University of Southern California-NIH/NCI (Co-Principal Investigator) |
R01 CA 059705 | Pathogenesis of Human Prostate Carcinoma - Subcontract |
| NIH/NCI (Co-Investigator) | RO1 CA 130916 | Role of Dystroglycan in Prostate Cancer Progression |
| Prostate Cancer Foundation (Co-Principal Investigator) | R21 CA 137490 | Mouse Model of Obesity and Prostate Cancer Progression |
| RESEARCH STAFF Oskar Rokhlin, Ph.D. Emeritus Adjunct Professor 319-335-8214 Rebecca Glover Research Assistant III 319-335-8658 Natalya Guseva Assistant Research Scientist 319-353-4068 |