Faculty
| DAVID K. MEYERHOLZ, D.V.M., Ph.D. Assistant Professor Director, Comparative Pathology Laboratory Director, Histology Research Laboratory 1165 Medical Laboratories Iowa City, IA 52242-1181 D.V.M. Iowa State University, Ames, 1994 Ph.D. Iowa State University, Ames, 2004 Diplomate, American College of Veterinary Pathologists Diplomate, American College of Veterinary Microbiologists (Virology) Associate Member, Center for Gene Therapy of Cystic Fibrosis and Other Genetic Disease |
Research: Dr. Meyerholz is a veterinary pathologist with a major interest in pulmonary pathology, immunity and disease. His research involves examination, detection and interpretation of cellular changes associated with cystic fibrosis, RSV, influenza, SARS-CoV and other pulmonary diseases. His lab specializes in anatomic phenotyping of new CF models (e.g. pig, ferret) and in developing novel morphologic techniques for the detection of cellular disease markers in the lung. In addition, his lab investigates regulation of inflammatory mediators in acute model of pancreatis model, phenotypic characterization of novel oncogenes, and immunopathology associated with chronic ethanol ingestion.
Dr. Meyerholz directs the Comparative Pathology Laboratory (CPL), which provides UI Investigators with scientific support including necropsy, gross and microscopic examination/interpretation, comprehensive anatomic phenotyping, histology services and scientific consultation.
Interests: Atherosclerosis, Bone healing, Cancer pathobiology, Comparative pathology, Cystic fibrosis, Developmental disease, Ethanol-associated immunopathology, Models of human disease, Pancreatitis, Pulmonary pathology, Viral pathogenesis (e.g. Influenza, RSV, SARS-CoV, etc.)
Selected Publications:
Rogers CS*, Stoltz DA*, Meyerholz DK*, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray, Jr. PB, Zabner J, Prather RS Welsh MJ. Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Piglets. Science, 2008, Sep 26;321(5897):1837-41.
(*contributed equally to the work)
Meyerholz DK, Williard DE, Grittmann AM, Samuel I. Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury. American Journal of Surgery, 196:675-82, 2008
Meyerholz DK, Edsen-Moore M, McGill J, Coleman RA, Cook RT, Legge KL. Chronic alcohol consumption increases the severity of murine influenza virus infections. Journal of Immunology, 181:641-648, 2008
Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray Jr PB, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. The Porcine Lung as a Potential Model for Cystic Fibrosis. Am J Physiol Lung Cell Mol Physiol. 295:L240-63, 2008
Castilow, EM, Meyerholz DK, Varga SM. IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease. Journal of Immunology. 180:2376-2384, 2008.
Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. SARS-CoV infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. Journal of Virology, 82:7264-7275, 2008
George CL, Goss KL, Meyerholz DK, Lamb FS, Snyder JM. Surfactant associated protein-A provides critical immunoprotection in neonatal mice. Infection and Immunity, 76:380-390, 2008.
(See complete publications list at PubMed)