Faculty
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MATTHEW D. KRASOWSKI, M.D., Ph.D. Clinical Associate Professor Vice-Chair for Clinical Affairs Director of Clinical Laboratories Medical Director, Clinical Chemistry and Point of Service Laboratories 200 Hawkins Drive - C671 General Hospital Iowa City, IA 52242-1009 Ph.D. University of Chicago, 1999 M.D. University of Chicago, 2001 Pathology Residency, University of Chicago, 2001-2004 Clinical Pharmacology & Pharmacogenomics Fellowship, University of Chicago, 2003-2005 |
As Director of the Clinical Laboratories, my goal is to provide the clinical laboratories with the latest diagnostic laboratory technology and to ensure that laboratory testing at the University of Iowa Hospitals and Clinics is used in a medically appropriate, cost-effective manner.
As the Medical Director of the Clinical Chemistry and Point of Service Laboratories, I am interested in all aspects of diagnostic chemistry, including cardiac markers, endocrinology, therapeutic drug monitoring, and toxicology. I have used computational methods to predict cross-reactivity of immunoassays used in clinical chemistry, especially those used for drug of abuse screening and therapeutic drug monitoring. My basic research interests include drug metabolism, toxicology, and bile acids. In terms of educational activities, I am director of the two-week medical school clerkship on laboratory medicine and am interested in developing novel methods of teaching laboratory medicine to medical students and residents.
Selected publications:
Krasowski MD. Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications. Pharmaceuticals (Basel). 2010 Jun 11;3(6):1909-1935. [PMID: 20640233].
Ekins S, Williams AJ, Krasowski MD, Freundlich JS. In silico repositioning of approved drugs for rare and neglected diseases. Drug Discov Today 2011 Apr;16(7-8):298-310. [PMID: 21376136]
Hagey LR, Vidal N, Hofmann AF, Krasowski MD. Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. BMC Evol Biol. 2010 May 6;10:133. [PMID: 20444292].
Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY; Academy of Clinical Laboratory Physicians and Scientists. Educating medical students in laboratory medicine: a proposed curriculum. Am J Clin Pathol. 2010 Apr;133(4):533-42. [PMID: 20231605].
Hagey LR, Møller PR, Hofmann AF, Krasowski MD. Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. Physiol Biochem Zool. 2010 Mar-Apr;83(2):308-21. [PMID: 20113173]
Hofmann AF, Hagey LR, Krasowski MD. Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res. 2010 Feb;51(2):226-46. [PMID: 19638645].
Krasowski MD, Siam MG, Iyer M, Pizon AF, Giannoutsos S, Ekins S. Chemoinformatic methods for predicting interference in drug of abuse/toxicology immunoassays. Clin Chem 55(6): 1203-1213, 2009. [PMID: 19342505]
Krasowski MD, Siam MG, Iyer M, Ekins S. Molecular similarity methods for predicting cross-reactivity with therapeutic drug monitoring immunoassays. Ther Drug Monit 31(3): 337-344, 2009. [PMID: 19333148]
Krasowski MD, Pizon AF, Siam MG, Giannoutsos S, Iyer M, Ekins S. Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine. BMC Emerg Med 9: 5, 2009. [PMID: 19400959]
Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann AF, Krasowski MD. Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res 49(7): 1577-1587, 2008. [PMID: 18362391]
Genzen JR, Krasowski MD. Resident training in clinical chemistry. Clin Lab Med 27(2): 343-358, 2007. [PMID: 17556088]