Faculty
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JAMES A. GOEKEN, M.D.
Professor Emeritus
Immunopathology
Pathology - 387 Medical Research Center
Iowa City, IA 52242-1182
M.D. University of Missouri, 1972
Internal Medicine Internship, The University of Iowa,
1972-73
Pathology Residency, The University of Iowa,
1973-76 |
Interests:
Immunopathology/Immunopathogenesis of Vasculitis
Anti-neutrophil cytoplasmic antibody and the several forms of vasculitis/crescentic glomerulonephritis associated with it are under investigation. Current studies involve outcomes analysis of ANCA (+) patients to determine the contribution of ANCA to improved diagnosis and therapy, assessment of newer test methods for ANCA in the clinical laboratory, and further delineation of the spectrum of ANCA-associated diseases. Of special interest are the rarer forms of vasculitis and renal disease occasionally seen in ANCA (+) patients, including medullary capillaritis and erythema elevatum diutinum.
Immunopathology/Immunopathogenesis of Inflammatory Bowel and Liver Diseases Associated with "atypical" P-ANCA
"Atypical" P-ANCA has been associated with inflammatory bowel and liver diseases (IBLD) [Hardarson S, LaBrecque D, Mitros F, Goeken J: Anti-Neutrophil Cytoplasmic Antibody (ANCA) in Inflammatory Bowel and Hepatobiliary Diseases. High Prevalence in Ulcerative Colitis, Primary Sclerosing Cholangitis and Autoimmune Hepatitis. Am J Clin Pathol 99:277-281, 1993]. The antigenic specificity of this autoantibody has yet to be defined. Studies to evaluate the contribution of this form of ANCA to diagnosis and management of IBLD are under development.
Serological Evaluation of Gluten-Sensitive Enteropathy and Associated Diseases
Gluten-sensitive enteropathy (GSE) has previously been reported to be uncommon in the U.S. as compared with Europe. A recent study in our laboratory indicates the incidence is really comparable in the Iowa population and most European centers. Anti-endomysial IgA antibody is the most sensitive and specific assay available only in specialized centers. The antigen involved is uncharacterized. We are attempting to purify and characterize this antigen to develop a quantitative Enzyme-immunoassay (EIA) for serological evaluation of patients with GSE.
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