Cyclosporine
| Label Mnemonic: | CYSP |
| Epic code: | LAB601 |
| Order form: | Laboratory Requisition |
| Supply order: | Supply Order Form |
| Billing: | Billing Policies |
| CPT code: | 80158 |
Specimen(s):
Whole Blood
Collection Medium:
 |
| Lavender top tube 3 mL (EDTA) |
Alternate
Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
Full 3 mL lavender top (EDTA) tube or ONE lavender top (EDTA)
microtube for pediatric patients.
Testing
Schedule:
Results are available 1200 Monday-Sunday. Samples need to be in lab by
0900 for results at 1200 (daily).
Comments:
Analysis performed using the Abbott Diagnostics Cyclosporine
immunoassay on the Architect platform. The general therapeutic range
for cyclosporine is 100-300 ng/mL. The optimal therapeutic range for a
given patient may differ from this suggested range based on the
indication for therapy, treatment phase (initiation or maintenance),
use in combination with other drugs, time of specimen collection
relative to prior dose, type of transplanted organ, and/or the
therapeutic approach of the transplant center. Cyclosporine whole
blood concentrations can be measured by either immunoassay or
chromatographic methodologies. These two methodologies are not
directly interchangeable, and the measured cyclosporine whole blood
concentration depends on the methodology used. Reference ranges may
vary according to the specific immunoassay or HPLC-MS/MS test.
Generally, immunoassays have been reported to have a positive bias
relative to HPLC-MS/MS assays due to the detection of antibody cross-
reactivity with cyclosporine metabolites.
Methodology:
Chemiluminescent Microparticle Immunoassay (CMIA)
Instructions:
Draw before next dose.
Sample
Processing:
Submit whole blood in original container. DO NOT CENTRIFUGE.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.
Sample
Storage:
Refrigerate.
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
All sample storage requirements are intended for delivery to UIHC within 24 hours of collection for testing. If samples won't arrive in this time period, please call the UIHC Core Lab for alternative storage/shipping instructions (319-356-3527).
Transport
Instructions:
Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.
CPT Code:
80158