Buprenorphine, Urine, Quant Reflex
Label Mnemonic: BUPRURR
Epic code: LAB8610
Supply order: Supply Order Form
Billing: Billing Policies
CPT code: 80348
Specimen(s):
Random Urine
Collection Medium:
Urine (Random)-BD Vacutainer®, no additive yellow top
Minimum:
Preferred Minimum: 2 mL Random Urine
Absolute Minimum: 1 mL Random Urine
Turn Around Time:
1-4 days upon receipt at reference laboratory.
Reference Range:
Drugs Covered                   Cutoff Concentrations
Buprenorphine                          2 ng/mL
Norbuprenorphine                       2 ng/mL
Buprenorphine glucuronide              5 ng/mL
Norbuprenorphine glucuronide           5 ng/mL
Naloxone                               100 ng/mL
Interpretive Data:
Positive cutoff:
Buprenorphine 2 ng/mL
Norbuprenorphine 2 ng/mL
Buprenorphine glucuronide 5 ng/mL
Norbuprenorphine glucuronide 5 ng/mL
Naloxone 100 ng/mL

For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug is common and may indicate use of parent drug during the prior week. Naloxone is included to detect the addition of a naloxone-containing drug directly into the urine.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.
Comments:
For general screening, Buprenorphine, Urine Screen (LAB8779) is preferred.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Sample Processing:
Submit urine in leak-proof plastic container.
Label transport tube with two patient identifiers, date and time of collection.
Sample Storage:
Refrigerate.
Transport Instructions:
Place requisition into outside pocket of bag.
Place specimen into zip-lock type bag, seal bag.
Transport in cooler with refrigerated coolant packs.
CPT Code:
80348