RNP Antibody

Label Mnemonic:	RNP
Epic code:	LAB1249
Order form:	Laboratory Requisition
Supply order:	Supply Order Form
Billing:	Billing Policies
CPT code:	86235

Specimen(s):

Plasma

Collection Medium:

Plasma Separator Tube 4.5 mL

Alternate Collection Media:

Call laboratory for additional acceptable specimen collection containers.

Minimum:

3.0 mL whole blood from light green top tube or TWO Microtainer^® devices

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Turn Around Time:

3 hours (upon receipt in laboratory)

Reference Range:

1.0 AI (antibody index) or less

Interpretive Data:

This test covers both RNP A and RNP 68. RNP antibodies occur in approximately 50% of patients with lupus erythematosus (LE) and may also occur in patients with other connective tissue diseases, notable mixed connective tissue disease (MCTD). MCTD is characterized by high levels of RNP antibodies without detectable Smith (Sm) or double- stranded DNA antibodies.

Comments:

Assay methodology and reference ranges changed February 25, 2013.

Methodology:

Multiplex flow immunoassay

Sample Processing:

Centrifuge at a speed and time necessary to get barrier separation of plasma/serum and cells within 1 hour of collection. Send specimen in original tube. Do Not transfer to another tube.
Each sample must be labeled with at least TWO full patient identifiers (First/Last Name & DOB are sufficient for non-UIHC affiliated clients) to avoid sample rejection/delays.

Sample Storage:

Refrigerate.

Transport Instructions:

Place labeled specimen into zip-lock type biohazard bag; seal bag.
Place completed requisition into outside pocket of bag.
Transport in cooler with refrigerated coolant packs.

CPT Code:

86235