Estrogen Receptor
Order Code: IERF
Order Form: Anatomic Pathology Consult Requisition
Specimen:
Tissue or FNA
Testing Schedule:
0800-1630 Monday through Friday.
Turn Around Time:
2 days
Reference Range:
The pathologist will provide an interpretive report.
Comments:
Estrogen Receptor (ER) expression status in breast carcinoma is an important prognostic and predictive biomarker according to recently published guidelines. ER status determination has become a part of the routine assessment of these tumors. About 60-70% of these tumors are ER positive, and this is associated with a more favorable prognosis than ER negative tumors. Immunohistochemical assessment of ER (as well as progesterone receptor) status has been recently documented to be superior to ligand binding assays in predicting response to hormonal manipulation in breat carcinoma. Immunohistochemical staining is performed on formalin-fixed, paraffin-embedded sections of tumor. An immunohistochemical (IHC) score is generated by the interpreting pathologist. A score of >2 has been used to define ER positivity.
Methodology:
Immunohistochemistry
Instructions:
Contact University of Iowa Diagnostic Laboratories
1-866-844-2522 (toll free)
319-384-7213 (Fax)
CPT Code:
88342 Estrogen Receptor 88342-26 Estrogen Receptor Professional Interpretation
 
See also:
Progesterone Receptor, Tissue or FNA
 
See Additional Information:
Consultation Overview