Lamotrigine (Lamictal)
Order Code: LAMT
Order Form: Laboratory Requisition
Specimen:
Whole Blood
Collection Medium:
Pink top tube
Alternate Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
5 mL pink top tube (adults) or TWO EDTA microtainers (pediatric pateints).
Rejection Criteria:
Gel separator tubes
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Turn Around Time:
2 hours (upon receipt in laboratory)
Reference Range:
Therapeutic range: 3 - 14 mcg/mL.
Comments:
The proposed therapeutic range for seizure control is 3 - 14 mcg/mL. Concentrations that exceed 15 mcg/mL may contribute to adverse effects. Pharmacokinetics varies widely, particularly with co-medications and/or compromised renal function.
Test Limitations:
Hemolysis: No significant interference up to an H index of 1000 (approximate hemoglobin concentration: 1000 mg/dL).

Lipemia: No significant interference up to an L index of 1000 (approximate triglycerides concentration: 1000 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.

Icterus: No significant interference up to an I index of 70 (approximate conjugated and unconjugated bilirubin concentration: 70 mg/dL).
Methodology:
Enzyme Immunoassay
Sample Processing:
Centrifuge immediately after drawing specimen.
Centrifuge at 3000 RPM for 10 minutes.
Aliquot plasma into labeled container and cap.
Sample Storage:
Refrigerate.
Transport Instructions:
Place requisition into outside pocket of bag.
Place specimen into zip-lock type bag, seal bag.
Transport in cooler with refrigerated coolant packs.
CPT Code:
83519