Specimen

Serum

Collection Medium:

Minimum:

Collect TWO full red top or lavender top tubes.

Recommended minimum:  4.0 ml serum or plasma
Absolute minimum:     2.5 ml serum or plasma

Analytic Time:

7 working days

Reference Range:

              Unexposed non-tobacco user   Passive exposure
Nicotine          Less than 2 ng/mL        Less than 2 ng/mL
Cotinine          Less than 2 ng/mL        Less than 8 ng/mL
3-OH-Cotinine     Less than 2 ng/mL        Less than 2 ng/mL
              Abstinent user for more      Active tobacco product use
                    than 2 weeks
Nicotine          Less than 2 ng/mL           30 - 50 ng/mL
Cotinine          Less than 2 ng/mL          200 - 800 ng/mL
3-OH-Cotinine     Less than 2 ng/mL          100 - 500 ng/mL

Reference range source:  Clinical Chemistry 48:9 1460-1471, 2002

Interpretive Data:

1. Compounds covered: nicotine, cotinine, 3-OH-cotinine.
2. Positive cutoff: 2 ng/mL

Comments:

No gel separator tubes.

Computer Code = NICO

Methodology:

Tandem Mass Spectrometry

CPT Code:

83887