Methylmalonic Acid, Quantitative, Urine

Order Code:	MMAUR
Epic Lab Code:	LAB3601
Order Form:	A-1a Miscellaneous Request or Epic Req

Commercial Mail-out Laboratory
01250 PFP
356-3527

Specimen:

Urine More information

Collection Medium:

Urine - 24 hour/timed plastic urine container

Minimum:

Preferred Minimum: 4 mL urine
Absolute Minimum: 0.5 mL urine

24 hour collection in a plastic container, refrigerate during collection is also accepted by the reference lab.

Rejection Criteria:

Room temperature specimens.

Delivery Instructions:

Submit specimen to laboratory as soon as possible after collection period is completed.

Turn Around Time:

1-3 days upon receipt at reference laboratory.

Reference Range:

Components Reference Interval Methylmalonic Acid, Urine 0.0-3.6 mmol/mol CRT Creatinine (24-hour) Male Female 3-8 yrs: 140-700 mg/d 3-8 yrs: 140-700 mg/d 9-12 yrs: 300-1300 mg/d 9-12 yrs: 300-1300 mg/d 13-17 yrs: 500-2300 mg/d 13-17 yrs: 400-1600 mg/d 18-50 yrs: 1000-2500mg/d 18-50 yrs: 700-1600 mg/d 51-80 yrs: 800-2100 mg/d 51-80 yrs: 500-1400 mg/d 81 yrs+: 600-2000 mg/d 81 yrs+: 400-1300 mg/d

Interpretive Data:

Elevated urinary methylmalonic acid is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.

Methodology:

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

CPT Code:

83921

See Additional Information:
Urine Tests Requiring Preservatives, Refrigeration or Special Containers