Carbamazepine Epoxide & Total
Order Code: CBZ-EP
Epic Lab Code: LAB21
Order Form: A-1a Miscellaneous Request or Epic Req
Commercial Mail-out Laboratory
6240 RCP
356-3527
Specimen:
Serum
Collection Medium:
Red top tube
Minimum:
Preferred Minimum: 2.0 mL serum Absolute Minimum: 0.5 mL serum
Rejection Criteria:
Citrated plasma. Tubes that contain liquid anticoagulant.
Specimen Instructions:
Separate serum from cells as soon as possible.
Analytic Time:
5 days upon receipt at reference laboratory
Reference Range:
Components Therapeutic Range Carbamazepine-10, 11 Epoxide Not well established Total Carbamazepine 4.0-12.0 mcg/mL Toxic Range: Greater than 20.0 mcg/mL The 10-11 epoxide metabolite has anticonvulsant activity similar to the parent drug. The expected range following chronic therapeutic dose (5.2 - 20.0 mg/kg) of carbamazepine is 0.5 - 2.0 mcg/mL.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Quantitative Immunoassay
CPT Code:
Carbamazepine, Total, 80156; Carbamazepine, Epoxide, 82486
 
See also:
Carbamazepine, Plasma