Specimen

Serum or Plasma

Collection Medium:

Alternate
Collection Media:

Lavender top tube (EDTA)

Minimum:

4 mL serum or EDTA plasma

Rejection Criteria:

Gel separator tubes

Analytic Time:

2 weeks

Reference Range:

Allopurinol:
    Reporting Limit:  0.10 mcg/mL
    Peak plasma/serum levels following a 300 mg single oral dose:
         1.4 - 2.6 mcg/mL at 0.5 to 2 hours post dose.

Oxypurinol:
    Reporting Limit:  0.30 mcg/mL
    Peak oxypurinol plasma/serum levels following a 300 mg Allopurinol
    oral dose:
         4.4 - 7.8 mcg/mL at 2 to 5 hours post dose.

Steady state serum trough level of Oxypurinol following a daily regimen 
of 300 mg Allopurinol per day:
         3.4 - 19.4 mcg/mL.

Methodology:

High Performance Liquid Chromatography

CPT Code:

82491