Collect second morning void or 24 hr urine. Sample must be refrigerated during collection. No preservative. Adult preferred minimum: 1.0 ml Adult absolute minimum 0.5 ml Pediatric minimum: 0.5 ml

Age Male Female 7-9 yrs 167-578 nM BCE/mM creatinine 201-626 nM BCE/mM creatinine 10-12 yrs 152-505 nM BCE/mM creatinine 173-728 nM BCE/mM creatinine 13-15 yrs 103-776 nM BCE/mM creatinine 38-515 nM BCE/mM creatinine 16-17 yrs 34-313 nM BCE/mM creatinine 20-144 nM BCE/mM creatinine 18 yrs & older 21-83 nM BCE/mM creatinine Premenopausal 17-94 nM BCE/mM creatinine Postmenopausal 26-124 nM BCE/mM creatinine NTx Units = nM BCE/mM Creatinine NTx = Cross-linked N-telopeptide of Type I Collagen BCE = Bone collagen equivalent A decrease of 30-40% from the NTx baseline after 3 months of therapy is a typical response to anti-resorptive therapy.

For monitoring therapy, a baseline sample should be collected prior to initiation of therapy. Subsequent samples for comparison should be collected at the same time of day as the baseline sample. Please print, complete and submit the Advance Beneficiary Notice (ABN) along with the Laboratory Requisition before shipping the specimen.