F-Actin (Smooth Muscle) Antibody, IgG with Reflex to IgG Titer
Label Mnemonic: | ACTIN |
Epic code: | LAB8686 |
Order form: | Epic Req |
Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum
Collection Medium:
Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum: 1 mL serum
Absolute Minimum: 0.25 mL serum
Absolute Minimum: 0.25 mL serum
Rejection Criteria:
Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic
specimens.
Turn Around
Time:
1-5 days upon receipt at reference laboratory
Reference Range:
F-Actin (Smooth Muscle) Ab, IgG by ELISA 19 Units or less Negative 20-30 Units Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen. 31 Units or greater Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis. Smooth Muscle Antibody, IgG Titer Less than 1:20 Negative - No Antibody detected. 1:20-1:80 Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen. 1:160 or greater Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis.
Interpretive Data:
Refer to report.
Comments:
In viral hepatitis the titers are generally less than 1:80 and are
transient. The titers in primary biliary cirrhosis are also low,
ranging from 1:20 to 1:40.
If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply.
If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply.
Methodology:
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative
Indirect Fluorescent Antibody
CPT Code:
83516; if titer performed, 86256