FISH, HES/Leukemia, 4q12 Rearrangement (FIP1L1-PDGFRA)
Order Code: FIP
Epic Lab Code: LAB4805
Order Form: A-1a Miscellaneous Request or Epic Req
Commercial Mail-out Laboratory
6240 RCP
356-3527
Specimen:
Bone Marrow or Whole Blood
Collection Medium:
Green top tube 4 mL (Na Heparin)
Minimum:
Absolute Minimum: 1 mL bone marrow or 3 mL whole blood
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.
Specimen Instructions:
Collect Monday - Thursday only. Do not collect before a weekend or holiday. Specimen must be received by referral laboratory within 72 hours of collection.
Testing Schedule:
Reference laboratory sets this test up on Mondays. Reports 8-16 days after set-up.
Analytic Time:
10 days upon receipt
Interpretive Data:
FIP1L1-PDGFRa fusion (rearrangement of 4q12; interstitial deletion of CHIC2 region) is observed in diverse eosinophilia-associated hematologic disorders. The cases with FIP1L1-PDGFRa fusion show an excellent response to the tyrosine kinase inhibitor imatinib mesylate (Metzgeroth et al, 2007).
Comments:
To order this test on a paraffin block, contact the Bone Marrow Lab in Core. Please call 356-2543 for assistance. The Bone Marrow Lab will work directly with the Mailout Lab to facilitate testing.
Methodology:
Fluorescence in situ hybridization (FISH)
CPT Code:
88275, 88271 (x3)