Amino Acids, Quantitative
| Label Mnemonic: | AMINOC |
| Epic code: | LAB4626 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
CSF
Specimen
Instructions:
Collect specimen from second collection vial. Send specimen in plastic
vial.
Collection Medium:
) |
| CSF collection kit |
Minimum:
0.1 mL of spinal fluid from second collection vial.
Rejection Criteria:
Specimens other than CSF.
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.Turn Around
Time:
3 days upon receipt at reference laboratory (not reported on Saturday
or Sunday)
Reference Range:
Age Groups CSF Amino Acid Referemce Values < or = 31 D 1-23 M 2-18 Y > 19 Years (nmol/mL) (n=73) (n=88) (n=189) (n=32) ----------------------------------------------------------------------- Phosphoserine (PSer) <1 <1 <1 <1 Phosphoethanolamine (PEtN) <15 <10 <8 <7 Taurine (Tau) 8-48 <28 <13 <20 Asparagine (Asn) 8-34 5-16 <10 5-20 Serine (Ser) 44-136 26-71 21-51 19-40 Hydroxyproline (Hyp) <7 <3 <1 <2 Glycine (Gly) 5-115 <33 <11 <35 Glutamine (Gln) 467-1832 301-1128 326-1092 380-1348 Aspartic Acid (Asp) <1 <1 <1 <2 Ethanolamine (EtN) 11-193 7-155 7-153 7-153 Histidine (His) 11-70 9-28 9-21 9-28 Threonine (Thr) 32-143 11-77 14-38 23-57 Citrulline (Cit) <11 <6 <3 <9 Sarcosine (Sar) <1 <1 <1 <1 Beta-alanine (bAla) <26 <25 <25 <25 Alanine (Ala) 24-124 16-53 12-34 19-60 Glutamic Acid (Glu) <12 <3 <1 <4 1-Methylhistidine (1MHis) <3 <1 <2 <3 3-Methylhistidine (3MHis) <4 <1 <1 <2 Argininosuccinic Acid (Asa) <1 <2 <1 <1 Carnosine (Car) <1 <1 <1 <1 Anserine (Ans) <9 <9 <7 <3 Homocitrulline (Hcit) <3 <1 <1 <1 Arginine (Arg) 5-39 11-35 11-27 11-32 Alpha-aminoadipic <1 <1 <1 <1 Acid (Aad) Gamma-amino-n-butyric <1 <1 <1 <1 Acid (GABA) Beta-aminoisobutyric <1 <1 <1 <1 Acid (bAib) Alpha-amino-n-butyric <15 <6 <5 <14 Acid (Abu) Hydroxylysine (Hyl) <1 <1 <1 <1 Proline (Pro) <17 <6 <2 <6 Ornithine (Orn) <24 <12 <6 <11 Cystathionine (Cth) <1 <2 <1 <1 Cystine (Cys) <2 <2 <1 <1 Lysine (Lys) 11-63 9-33 10-25 13-42 Methionine (Met) <43 <9 <6 <10 Valine (Val) 14-61 9-28 8-20 11-40 Tyrosine (Tyr) 8-83 5-24 <17 5-17 Homocystine (Hcy) <1 <1 <1 <1 Isoleucine (Ile) <27 <13 <8 <17 Leucine (Leu) 12-41 6-21 7-16 7-29 Phenylalanine (Phe) 7-40 5-18 <12 7-21 Tryptophan (Trp) <12 <6 <4 <4 Allo-isoleucine (AlloIle) <3 <2 <2 <2
Interpretive Data:
When no significant abnormalities are detected, a simple descriptive
interpretation is provided. When abnormal results are detected, a
detailed interpretation is given. This interpretation includes an
overview of the results and their significance, a correlation to
available clinical information, elements of differential diagnosis,
and
recommendations for additional biochemical testing and in
vitro confirmatory studies (enzyme assay, molecular analysis),
name and phone number of key contacts who may provide these studies at
the reference laboratory or elsewhere, and the telephone number to
reach one of the laboratory directors in case the referring physician
has additional questions.
Comments:
Useful For:
Evaluating patients with possible inborn errors of amino acid metabolism, in particular nonketotic hyperglycemia and serine biosynthesis defects, especially when used in conjunction with concomitantly drawn plasma specimens.
Cautions:
Proper specimen collection and handling are crucial to achieve reliable results. Blood contamination can interfere with test results.
Evaluating patients with possible inborn errors of amino acid metabolism, in particular nonketotic hyperglycemia and serine biosynthesis defects, especially when used in conjunction with concomitantly drawn plasma specimens.
Cautions:
Proper specimen collection and handling are crucial to achieve reliable results. Blood contamination can interfere with test results.
Methodology:
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Includes quantitation of the following amino acids: taurine, threonine, serine, asparagine, glutamic acid, glutamine, proline, glycine, alanine, citrulline, a-amino-n-butyric acid, valine, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, ornithine, lysine, histidine, and arginine.
Includes quantitation of the following amino acids: taurine, threonine, serine, asparagine, glutamic acid, glutamine, proline, glycine, alanine, citrulline, a-amino-n-butyric acid, valine, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, ornithine, lysine, histidine, and arginine.
CPT Code:
82139