Specimen

Whole Blood

Collection Medium:

Alternate
Collection Media:

Yellow top tube (ACD solution A)

Minimum:

Draw blood in a lavender-top (EDTA) tube(s) or a yellow-top (ACD)
tube(s), and send 3.0 mL of EDTA or ACD whole blood in original 
VACUTAINER(S).

Delivery Instructions:

Specimen must arrive commerical laboratory within 96 hours of draw.

Analytic Time:

within 10 days

Reference Range:

An interpretive report will be provided.

Comments:

Extracted DNA is also an appropriate sample type.

Methodology:

DNA sequencing and dosage analysis are utilized to test for the 
presence of a mutation in all 19 exons of the hMLH1 gene and all 16 
exons of the hMSH2 gene Polymerase chain reaction (PCR).

CPT Code:

DNA Sequence Analysis:  83891, 83892(x4), 83900, 83901 (x2),
                        83909 (x70), 83912

Gene Dosage Analysis:   83896, 83901, 83909