Specimen:

Tissue

Testing Schedule:

0800-1630 Monday through Friday.  For additional services, 
contact Clinical Pathology Resident on-call at pager #3404.

Analytic Time:

3 days

Reference Range:

The pathologist will provide an interpretative report.

Comments:

Please send a Surgical Pathology H-1 form to Immunopathology with this 
request.

C-erb-2 oncoprotein is the product of the HER-2 (neu) oncogene which is 
overexpressed in a variety of adenocarcinomas arising at various sites. 
Overexpression of c-erb-2 is present in 15-30% of cases of breast 
carcinoma and has been demonstrated to be a negative prognostic 
indicator.

C-erb-2 overexpression can be detected by immunohistochemical staining 
of formalin-fixed paraffin-embedded sections of tumor tissue. Membrane 
staining of the cells is the only reaction considered positive. A 
positive therapeutic response to Herceptin (TM) therapy with 
anti-C-erb-2 monoclonal antibody has been reported in association with 
3+ staining intensity.

Methodology:

Immunohistochemistry

CPT Code:

88360 Cerb-2, 88360-26 Cerb-2 Professional Interpretation