Voriconazole Antifungal Drug Level, Serum

Voriconazole Antifungal Drug Level

Order Code:	VORI
Epic Lab Code:	LAB4267
Order Form:	A-1a Miscellaneous Request or Epic Req

Commercial Mail-out Laboratory
6240 RCP
356-3527

Specimen:

Serum

Collection Medium:

Red top tube

Minimum:

Draw blood in a plain red-top tube(s). Spin down and send 2 mL of serum frozen in plastic vial.

Analytic Time:

7 working days upon receipt at reference laboratory

Reference Range:

1.0-5.5 mcg/mL Trough level (i.e., immediately before the next dose) monitoring is recommended.

Interpretive Data:

Trough levels >6 mcg/mL (and especially >10 mcg/mL) have been associated with toxicity in several reports. Trough levels <1 mcg/mL have been associated with suboptimal response in several reports. Cautions: Voriconazole metabolism may be altered by coadministration of drugs that metabolically induce or inhibit CYP2C19 or by genetic polymorphisms that affect enzyme activity.

Methodology:

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

CPT Code:

82491