The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK

Neuron Specific Enolase, CSF
Order Code: NSECSF
Order Form: A-1a Miscellaneous Request or IPR Req 		  Commercial "Mail-out" Laboratory
6240 RCP
356-3527 
Specimen
 
Spinal Fluid
Collection Medium:
CSF container 


Minimum:


Requested Minimum:  1 mL CSF
Absolute Minimum:  0.5 mL CSF


Delivery Instructions:


Submit specimen to laboratory as soon as possible after collection.


Analytic Time:


1 week


Reference Range:


Normal: <=15 ng/mL
Indeterminate: 15-30 ng/mL
Elevated: >30 ng/mL
Elevated results may indicate the need for additional work-up.  
Possible causes may be NSE-secreting CNS/Leptomeningeal tumor or rapid 
neuronal destruction from a variety of causes. In the context of 
dementia, elevated results may be suggestive of Creutzfeldt-Jakob 
disease.


Methodology:


Homogeneous Time Resolved Fluorescence (HTRF) on the BRAHMS Kryptor 
Compact


CPT Code:


83520




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Updated: 07/16/2008

Note: The information contained in this handbook is  
            for use by personnel of University of Iowa Health Care. 
            No other use is implied or intended.