Specimen

Serum

Collection Medium:

Minimum:

Preferred minimum:           1.0 ml serum
Absolute Adult minimum:      0.5 ml serum
Absolute Pediatric minimum:  0.15 ml serum

Rejection Criteria:

Hemolyzed and severely lipemic specimens.

Testing Schedule:

Weekly

Analytic Time:

within 10 days

Reference Range:

Reference Interval:
Less than 1000 Titer Units (TU)

Interpretive Data:

Detection of IgM autoantibody against myelin associated glycoprotein 
(MAG) suggests active demyelination in peripheral neuropathy.  The 
possiblity of MAG antibody involvement in a suspected neuropathy may 
essentially be ruled out if a MAG IgM negative result is obtained.  
Detection of MAG IgM antibody by ELISA using human MAG (100 kD) antigen 
is significantly more sensitive and specific than MAG Western blot and 
IFA assays using primate antigen.

Methodology:

Enzyme-Linked Immunosorbent Assay  (ELISA)

CPT Code:

83516