Keppra (Levetiracetam)
| Order Code: | KEPPRA |
| Epic Lab Code: | LAB477 |
| Order Form: | A-1a Therapeutic Drug Analysis or Epic Req |
Chemistry
6240 RCP
356-3527
6240 RCP
356-3527
Specimen:
Whole Blood
Collection Medium:
 |
| Pink top tube |
Alternate
Collection Media:
Call laboratory for additional acceptable specimen collection containers.
Minimum:
5 mL pink top tube (adults) or TWO EDTA microtainers (pediatric
patients).
Rejection Criteria:
Gel separator tubes
Testing Schedule:
24 hrs/day, 7 days a week, including holidays.
Analytic Time:
2 hours (upon receipt in laboratory)
Reference Range:
Therapeutic range: 5-30 mcg/mL
Comments:
The proposed therapeutic range for seizure control is 5-30 mcg/mL.
Pharmacokinetics of levetiracetam are affected by renal function. The
relationship between serum concentrations and toxicity is not known.
Test
Limitations:
Hemolysis: No significant interference up to an H index of 1000
(approximate hemoglobin concentration: 1000 mg/dL).
Lipemia: No significant interference up to an L index of 1500 (approximate triglycerides concentration: 1500 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.
Icterus: No significant interference up to an I index of 70 (approximate conjugated and unconjugated bilirubin concentration: 70 mg/dL).
Lipemia: No significant interference up to an L index of 1500 (approximate triglycerides concentration: 1500 mg/dL). Note there is poor correlation between turbidity and triglyceride concentration.
Icterus: No significant interference up to an I index of 70 (approximate conjugated and unconjugated bilirubin concentration: 70 mg/dL).
Methodology:
Enzyme Immunoassay
CPT Code:
83519