Zonisamide (Zonegran) Drug Level
| Label Mnemonic: | ZONI |
| Epic code: | LAB504 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Core and Specialty Care Nursery |
Commercial Mailout Laboratory
6240-8 RCP
356-8593
6240-8 RCP
356-8593
Specimen(s):
Serum or Plasma
Specimen
Instructions:
Patient Preparation: Timing of specimen collection:
Pre-dose (trough) draw - At steady state concentration.
Separate serum from cells within 2 hours of collection.
Separate serum from cells within 2 hours of collection.
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Preferred Minimum 1 mL serum
Absolute Minimum: 0.5 mL serum
Absolute Minimum: 0.5 mL serum
Rejection Criteria:
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS
or ACD solution).
Delivery Instructions:
Submit specimen to laboratory as soon as possible after collection.Turn Around
Time:
4 days upon receipt at reference laboratory
Reference Range:
Therapeutic Range: Not well established.
Toxic Level: Greater than 80 μg/mL
Toxic Level: Greater than 80 μg/mL
Interpretive Data:
The proposed therapeutic range for seizure control is 10-40 μg/mL.
Toxic concentrations may cause coma, seizures and cardiac
abnormalities. Pharmacokinetics varies widely, particularly with co-
medications and/or compromised renal function.
Test
Limitations:
The proposed therapeutic range for seizure control is 10-40
μg/mL. Concentrations that exceed 80 μg/mL may contribute to
adverse effects. Pharmacokinetics varies widely, particularly with co-
medications and/or compromised renal function.
Methodology:
Quantitative Enzyme Multiplied Immunoassay Technique
CPT Code:
80203