UC-ANCA Screen and Interpretation
| Label Mnemonic: | UCANCAS |
| Epic code: | LAB1365 |
| Downtime form: | A-1a Doctor/Provider Orders - Pathology Immunopathology |
Immunopathology
5238 RCP
356-2688
5238 RCP
356-2688
Specimen(s):
Serum
Collection Medium:
 |
| Red top tube 5 mL (Clot Activator) |
Minimum:
Adult - 5 mL red top tube
Pediatric - 2 mL red top tube
Pediatric - 2 mL red top tube
Testing Schedule:
Daily - Batch analysis performed daily excluding
weekends and university holidays.
Turn Around
Time:
3 days
Reference Range:
<1:40 titer, includes interpretative report.
Comments:
"UC-ANCA" (also called "atypical P-ANCA" or "X-ANCA") is the type of
ANCA most commonly found in some patients with certain inflammatory
bowel and liver disease, namely, ulcerative colitis (72-80%), primary
sclerosing cholangitis (72-80%), and autoimmune hepatitis type 1
(50-80%). A subset of patients with Crohn's Disease limited to the
colon, may also be positive. Some patients with autoimmune connective
tissues diseases (including systemic lupus erythematosus, rheumatoid
arthritis and Felty's syndrome) may also have an autoantibody which
produces the "atypical P-ANCA" pattern.
Since the specificity of this autoantibody has not yet been conclusively identified (and there may be more than one specificity), there is no confirmatory test. It is important to order this test only in the clinical setting of inflammatory bowel or liver disease. Note: Very rare patients with ulcerative colitis or primary sclerosing cholangitis may have one of the vasculitis-related ANCA specificities (anti-MPO or PR3).
Titration of "UC-ANCA" is not performed as studies have found no correlation between titer and disease activity.
Since the specificity of this autoantibody has not yet been conclusively identified (and there may be more than one specificity), there is no confirmatory test. It is important to order this test only in the clinical setting of inflammatory bowel or liver disease. Note: Very rare patients with ulcerative colitis or primary sclerosing cholangitis may have one of the vasculitis-related ANCA specificities (anti-MPO or PR3).
Titration of "UC-ANCA" is not performed as studies have found no correlation between titer and disease activity.
Methodology:
Immunofluorescence
CPT Code:
86255 UC-ANCA Screen (Technical)
86255-26 UC-ANCA Screen (Professional Interpretation)
86255-26 UC-ANCA Screen (Professional Interpretation)