Amiodarone & Metabolite
| Order Code: | AMIO |
| Epic Lab Code: | LAB2580 |
| Order Form: | A-1a Miscellaneous Request or Epic Req |
Commercial Mail-out Laboratory
6240 RCP
356-3527
6240 RCP
356-3527
Specimen:
Serum
Collection Medium:
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| Red top tube |
Minimum:
Preferred Minimum: 2 mL serum
Absolute Minimum: 0.5 mL serum
Absolute Minimum: 0.5 mL serum
Rejection Criteria:
Citrated plasma. Tubes that contain liquid anticoagulant.
Delivery Instructions:
Wrap specimen in aluminum foil to protect from light.
Analytic Time:
1-2 days upon receipt at reference laboratory
Reference Range:
Therapeutic Range
Amiodarone: 1.0-3.0 mcg/mL
Desethylamiodarone: Not established
Potential toxic level: > 3.0 mcg/mL
Interpretive Data:
The therapeutic range of amiodarone is not presently well established.
Toxic effects may begin above 3.0 mcg/mL. The concentration of
desethylamiodarone, a major metabolite, is also reported, but no
therapeutic range is available. At steady-state, the metabolite
concentration is similar to the amiodarone concentration. This
metabolite may be pharmacologically active, but the extent of activity
is not known with certainty.
Comments:
Includes Desethylamiodarone.
Methodology:
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
CPT Code:
82491 (x2)
