Iron
Order Code: FET
Epic Lab Code: LAB3444
Order Form: A-1a Miscellaneous Request or Epic Req
Commercial Mail-out Laboratory
6240 RCP
356-3527
Specimen:
Liver Tissue
Collection Medium:
Miscellaneous container; contact laboratory
Minimum:
1 cm long specimen obtained with an 18 gauge needle. Tissue can be fresh, paraffin-embedded, formalin-fixed, or dried. Formalin is acceptable, but not preferred. Paraffin blocks are acceptable. Metal-free vial available from Specimen Control, 6240 RCP.
Rejection Criteria:
Specimens less than 0.25 mg dry weight. Samples stored or shipped in saline.
Analytic Time:
2-6 days upon receipt at reference laboratory
Reference Range:
Male: Hepatic Iron Content (HIC): 200 - 2,000 μg/g of tissue Hepatic Iron Index (HII): Less than 1.0 Female: Hepatic Iron Content (HIC): 200 - 1,600 μg/g of tissue Hepatic Iron Index (HII): Less than 1.0
Interpretive Data:
A Hepatic Iron Index (HII) is not calculated for patients less than 14 years. An HII less than 1.0 is consistent with normal iron accumulation. An HII 1.0 through 1.9 is consistent with mild iron accumulation such as in heterozygous hemochromatosis or alcoholic liver disease. An HII greater than 1.9 is consistent with iron overload such as in homozygous hemochromatosis, multiple transfusions, porphyria cutanea tarda, and cirrhotic liver disease. The HII will decrease with chronic blood loss or phlebotomy.
Comments:
Submit to Surgical Pathology 5804 JPP. Iron on Liver Tissue will be ordered if applicable by Pathologist review. Record age on test requisition in order to calculate iron index.
Methodology:
Inductively Coupled Plasma/Mass Spectrometry
CPT Code:
83789