Insulin Like Growth Factor I (IGF-I)
| Order Code: | IGFI |
| Epic Lab Code: | LAB3430 |
| Order Form: | A-1a Miscellaneous Request or Epic Req |
Commercial Mail-out Laboratory
6240 RCP
356-3527
6240 RCP
356-3527
Specimen:
Serum
Collection Medium:
 |
| Red top tube |
Minimum:
Absolute Minimum: 1 mL serum from red top tube
Rejection Criteria:
Slightly, moderate, and grossly icteric samples. Samples received at
room temperature. Frozen glass tubes.
Analytic Time:
8 working days upon receipt at reference laboratory
Reference Range:
Pediatric:
Age (Years) Female Age (Years) Male
<1* 17-185 ng/mL <1* < or = 142 ng/mL
1-1.9* 15-175 ng/mL 1-1.9* < or = 134 ng/mL
2-2.9* 16-178 ng/mL 2-2.9* < or = 135 ng/mL
3-3.9 38-214 ng/mL 3-3.9 30-155 ng/mL
4-4.9 34-238 ng/mL 4-4.9 28-181 ng/mL
5-5.9 37-272 ng/mL 5-5.9 31-214 ng/mL
6-6.9 45-316 ng/mL 6-6.9 38-253 ng/mL
7-7.9 58-376 ng/mL 7-7.9 48-298 ng/mL
8-8.9 76-424 ng/mL 8-8.9 62-347 ng/mL
9-9.9 99-483 ng/mL 9-9.9 80-398 ng/mL
10-10.9 125-541 ng/mL 10-10.9 100-449 ng/mL
11-11.9 152-593 ng/mL 11-11.9 123-497 ng/mL
12-12.9 178-636 ng/mL 12-12.9 146-541 ng/mL
13-13.9 200-664 ng/mL 13-13.9 168-576 ng/mL
14-14.9 214-673 ng/mL 14-14.9 187-599 ng/mL
15-15.9 218-659 ng/mL 15-15.9 201-609 ng/mL
16-16.9 201-610 ng/mL 16-16.9 209-602 ng/mL
17-17.9 185-551 ng/mL 17-17.9 207-576 ng/mL
*Brabant G, et al. Serum insulin-like growth factor 1 reference values
for an automated chemiluminescence immunoassay system: Result from a
multicenter study. Horm. Res. 2003; 60:53-60.
Female Tanner Stages (based on breast stage)
Age (Years) 1 2 3 4,5 UOM
8-8.9 80-307 84-414 197-642 388-871 ng/mL
9.9.9 92-332 91-432 197-642 358-823 ng/mL
10-10.9 105-359 99-451 197-642 330-776 ng/mL
11-11.9 118-387 107-470 197-642 304-731 ng/mL
12-12.9 133-416 115-490 197-642 278-688 ng/mL
13-13.9 148-447 123-510 197-642 254-646 ng/mL
Male Tanner Stages (based on testicular volume)
Age (Years) 1 2,3 4,5 UOM
10-10.9 84-315 78-418 349-817 ng/mL
Comments:
Insulin-like growth factor I (IGF-I, or somatomedin C), a protein
involved in stimulating somatic growth, is regulated principally by
growth hormone (GH) and nutritional intake. IGF-I is transported in
serum by several proteins; this helps maintain relatively high IGF-I
plasma levels and minimizes fluctuations in serum IGF-I
concentrations.
Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.
Methodology:
Liquid Chromatography Mass Spectrometry (LC/MS)