Non-allergic Adult: 0-100 IU/mL Non-allergic Children: 10-20% of adult values Neonates: 0-2 IU/mL Infants in 1st year of life: 0-15 IU/mL Children aged 1-5 years: 0-60 IU/mL Children aged 6-9 years: 0-90 IU/mL Children aged 10-15 years: 0-200 IU/mL

The assay is unaffected by icterus (bilirubin is less than 37 mg/dL), hemolysis (Hb is less than 100 mg/dL), lipemia (triglycerides is less than 2200 mg/dL) and biotin is less than 100 ng/mL. (criterion: recovery within plus or minus 10% of initial value). In patients receiving therapy with high biotin doses (i.e. is greater than 5 mg/day) no sample should be taken until at least 8 hours after the last biotin administration. No interference was observed from rheumatoid factor up to 6000 U/mL (method comparison: Elecsys IgE and a comparison IgE test on 50 samples). No high dose hook effect at IgE concentrations of up to 50 000 IU/mL (120000 ng/mL). In vitro tests were performed on 36 commonly used pharmaceuticals. No interference with the assay was found. As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from samples taken from patients who have been treated with monoclonal mouse antibodies or have received them for diagnostic purposes. In rare cases interference due to extremely high titers of antibodies to ruthenium can occur. IgE contains additives which minimize these effects. Extremely high titers of antibodies to streptavidin can occur in isolated cases and cause interference. For diagnostic purposes, the IgE findings should always be assessed in conjunction with the patient's medical history, clinical examination and other findings.