The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK

Amitriptyline/Nortriptyline Fractionation
Order Code: AMIT/NORT
Order Form: A-1a Therapeutic Drug Analysis or IPR Req 		  Commercial "Mail-out" Laboratory
6240 RCP
356-3527 
Specimen
 
Serum
Collection Medium:
Red top tube 


Alternate
Collection Media:


Lavender top tube (EDTA), Green top tube (Na Heparin)


Minimum:


Preferred minimum: 2 ml serum
Adult absolute minimum: 1.0 ml serum
Pediatric absolute minimum:  0.65 ml serum


Rejection Criteria:


Gel separator tubes.


Analytic Time:


4 working days


Reference Range:


Therapeutic Range
Total drug: 95-250 ng/mL
Report includes individual values for amitriptyline, nortriptyline and 
total.
Toxic:  >500 ng/mL


Methodology:


High Performance Liquid Chromatography


CPT Code:


80152 Amitriptyline, 80182 Nortriptyline


 


See Additional Information:
Critical Laboratory Values




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Updated: 05/14/2007

Note: The information contained in this handbook is  
            for use by personnel of University of Iowa Health Care. 
            No other use is implied or intended.