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UI Department of Internal Medicine

  William Tabayoyong

The focus of my research is to study the molecular mechanisms involved in immunoregulation by human regulatory T cells (Tregs).  It is well established that Tregs are capable of inhibiting CD4+ T cell proliferation and cytokine production; however the exact mechanism of Treg mediated immunosuppression is not clear.  The circulating pool of Tregs is also heterogeneous, comprised of a naturally occurring subset that arises during thymopoiesis, and a second peripheral subset that is generated upon conversion of non-regulatory T cells into Tregs.  Currently, we are able to isolate non-regulatory T cells from human cord blood and convert them into Tregs in vitro.  Future studies will determine the mechanisms involved in non-regulatory T cell conversion into Tregs and also the molecular mechanisms employed by these converted Tregs to suppress immune responses.

 

William Tabayoyong  
Kun-Ming Chan

Dr. Chan's research focuses on the differentiating Embryonic Stem cells toward definitive endoderm which many of the major organs including the liver, pancreas, lung, thyroid and intestines are derived from.  In order to efficiently produce the desired differentiated cell types from ESCs, derivation of specific intermediate cell types for further differentiation could lead to efficiently generated functional cell lineages. Thus, he is trying to differentiating Murine ESCs toward an intermediate cell type, definitive endoderm, by treating ESCs with Activin A under a serum-free culture condition. Then, the definitive endoderm cells are isolate by defined cell surface markers, and the newly isolated endodermal cells could be used for the derivation of insulin producing cells and hepatocytes.

Kun-Ming Chan  
 
 

   
     
     
     
     
     
     
     
   

 

     
     
     
     
     
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