Michael J. Welsh, M.D. |
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Abbreviated Biosketch:
Positions and Honors:
Year Position Institution 7/74-6/77 Intern/Resident Internal Medicine, University of Iowa 7/77-6/79 Research Fellowship Cardiovascular Research Institute, University of California, San Francisco 7/79-12/80 Research Fellow Physiology and Cell Biology, University of Texas Medical School, Houston 1/81-6/84 Assistant Professor Internal Medicine,University of Iowa 7/84-6/87 Associate Professor Internal Medicine, University of Iowa 7/87-present Professor Internal Medicine, University of Iowa 1989-present Professor Physiology and Biophysics, University of Iowa 1989-present Investigator Howard Hughes Medical Institute Recent Publications:
Singh PS, Parsek MR, Greenberg EP and Welsh MJ: A Component of Innate Immunity Prevents Bacterial Biofilm Development. Nature, 417:552-555, 2002.
Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH Jr and Welsh MJ: The Acid-Activated Ion channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory. Neuron, 34:463-477, 2002.
Walters RW, Freimuth P, Moninger TO, Ganske I, Zabner J and Welsh MJ: Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape. Cell, 110:789-799, 2002.
Leonard SA, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA and Welsh MJ: cAMP-Dependent Protein Kinase Phosphorylation of the Acid-Sensing Ion Channel-1 Regulates its Binding to PICK1. Proc. Natl. Acad. Sci. U.S.A., 100:2029-2034, 2003.
Zabner J, Karp P, Seiler M, Phillips SL, Mitchell CJ, Saavedra M, Welsh MJ and Klingelhutz AJ: Development of Cystic Fibrosis and Non-Cystic Fibrosis Airway Cell Lines. Am. J. Physiol., 284(5):L844-854, 2003.
Xie J, Price MP, Wemmie JA, Askwith CC and Welsh MJ: ASIC3 and ASIC1 Mediate FMRFamide-Related Peptide Enhancement of H+-Gated Currents in Cultured Dorsal Root Ganglion Neurons. J. Neurophysiol., 89(5):2459-2465, 2003.
Liu L, Johnson WA and Welsh MJ: Drosophila DEG/ENaC Pickpocket Genes are Expressed in the Tracheal System Where They May Be Involved in Liquid Clearance. Proc. Natl. Acad. Sci. U.S.A., 100:21288-2133, 2003.
Ostedgaard LS, Randak C, Rokhlina T, Karp P, Vermeer D, Ashbourne-Excoffon KJ and Welsh MJ: Effects of C-Terminal Deletions on CFTR Function in Cystic Fibrosis Airway Epithelia. Proc. Natl. Acad. Sci. U.S.A., 100:1937-1942, 2003.
Vermeer PD, Einwalter LA, Moninger TO, Rokhlina T, Kern JA, Zabner J and Welsh MJ: Segregation of Receptor and Ligand Regulates Activation of Epithelial Growth Factor Receptor. Nature, 422:322-326, 2003.
Liu L, Yermolaieva O, Johnson WA, Abboud FM and Welsh MJ: Identification and Function of Thermosensory Neurons in Drosophila Larva. Nat. Neurosci., 6(3):267-273, 2003.
Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH Jr and Welsh MJ: Acid-sensing Ion Channel 1 is Localized in Brain Regions With High Synaptic Density and Contributes to Fear Conditioning. J. Neurosci., 23(13):5496-5502, 2003.
Ainsley JA, Pettus JM, Bosenko D, Gerstein CE, Zinkevich N, Anderson MG, Adams CM, Welsh MJ, and Johnson WA. Enhanced Locomotion Caused by Loss of the Drosophila DEG/ENaC Protein Pickpocket1. Current Biology., 13:1557-1563, 2003.
Liu L, Leonard AS, Motto DG, Feller MA, Price MP, Johnson WA and Welsh MJ: Contribution of Drosophila DEG/ENaC Genes to Salt Taste. Neuron, 39:133-146, 2003.
Randak C and Welsh MJ. An Intrinsic Adenylate Kinase Activity Regulates Gating of the ABC Transporter CFTR. Cell 115(7):837-850, 2003.
Lee JH, Yi SMP, Anderson ME, Berger KL, Welsh MJ, Klingelhutz AJ, and Ozbun MA. Propagation of Infectious Human Papillomavirus Type 16 Using a Novel Adenovirus and Cre/LoxP Mechanism. Proc. Nat'l. Acad. Sci. USA, 101(7):2094-2099, 2004.
Scheetz TE, Zabner J, Welsh MJ, Coco J, Eyestone M, De Fatima Bonaldo M, Kucaba T, Casavant TL, Soares MB, and McCray PB Jr. Large Scale Gene Discovery in Human Airway Epithelia Reveals Novel Transcripts. Physiol. Genomics, 17(1):69-77, 2004.
Chun CK, Ozer EA, Welsh MJ, Zabner J, and Greenberg EP. Inactivation of a Pseudomonas aeruginosa Quorum-Sensing Signal by Human Airway Epithelia. Proc. Nat'l. Acad. Sci. USA, 101(10):3587-3590, 2004.
Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, Brennan TJ, Symonds E, Omari T, LewinGR, Welsh MJ, and Blackshaw LA. The Ion Channel ASIC1 Contributes to Visceral But Not Cutaneous Mechanoreceptor Function. Gastroenterology, 127(6):1739-1747, 2004.
Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, and Welsh MJ. Overexpression of ASIC1a in Transgenic Mice Increases Acquired Fear-Related Behavior. Proc. Nat'l. Acad. Sci. USA, 101(10):3621-3626, 2004.
Askwith CC, Wemmie JA, Price MP, Rokhlina T, and Welsh MJ. ASIC2 Modulates ASIC1 H+-Activated Currents in Hippocampal Neurons. J. Biol. Chem. 279(18):18296-18305, 2004.
Yermolaieva O, Leonard AS, Schnizler MK, Abboud FM, and Welsh MJ. Extracellular Acidosis Increases Neuronal Cell Calcium by Activating ASIC1a. Proc. Nat'l. Acad. Sci. USA, 101(17):6752-6757, 2004.
Xiong Z-G, Zhu X-M, Chu X-P, Minami M, Hey J, Wemmie JA, Price MP, Welsh MJ, and Simon RP. Neuroprotection in Ischemia: Blocking Calcium-Permeable Acid-Sensing Ion Channels. Cell, 118:687-698, 2004.
Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, and Welsh MJ. PSD-95 and Lin-7b interact with ASIC3 and have opposite effects on H+-gated current. J. Biol. Chem., 279(45):46962-46968, 2004.
Berger AL, Randak CO, Ostedgaard LS, Karp PH, Vermeer DW, and Welsh MJ. Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity. J Biol Chem. 280(7):5221-6, 2005.
Randak CO and Welsh MJ. ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity. Proc Natl Acad Sci U S A. 102(6):2216-20, 2005.
Berger AL, Ikuma M, Welsh MJ. Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain. Proc Natl Acad Sci U S A. 102(2):455-60, 2005.
Ostedgaard LS, Rokhlina T, Karp PH, Lashmit P, Afione S, Schmidt M, Zabner J, Stinski MF, Chiorini JA, and Welsh MJ. A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proc Natl Acad Sci U S A. 102(8):2952-2957, 2005.
Dajani R, Zhang Y, Taft PJ, Travis SM, Starner TD, Olsen A, Zabner J, Welsh MJ, and Engelhardt JF. Lysozyme Secretion by Submucosal Glands Protects the Airway From Bacterial Infection. Am J Respir Cell Mol Biol. 32(6):548-552, 2005.
Randak CO and Welsh MJ. Adenylate Kinase Activity in ABC Transporters. J. Biol. Chem. 280(41):34385-34388, 2005.
Farmen SL, Karp PH, Ng P, Palmer DJ, Koehler DR, Hu J, Beaudet AL, Zabner J, and Welsh MJ. Gene Transfer of CFTR to Airway Epithelia: Low Levels of Expression are Sufficient to Correct Cl- Transport and Overexpression can Generate Basolateral CFTR. Am. J. Physiol. 280:L1123-1130, 2005.
Vermeer PD, Panko L, Welsh MJ, and Zabner, J. ERBB1 Functions as a Sensor of Airway Epithelial Integrity by Regulation of Protein Phosphatase 2A Activity. J. Biol. Chem. 281:1725-1730, 2006.
Wemmie, JA, Price MP, and Welsh MJ. Acid-sensing Ion Channels: Advances, Questions, and Therapeutic Opportunities. Trends Neurosci. 29(10):578-586, 2006.
Zha X-M, Wemmie JA, Green SH, and Welsh MJ. ASIC1a is a Postsynaptic Proton Receptor that Affects the Density of Dendritic Spines. PNAS, 103:16556-16561, 2006.
Ben-Shahar Y, Nannapaneni K, Casavant TL, Schhetz TE,and Welsh MJ. Eukaryotic Operon-Like Transcrtiption of Functionally Related Genes in Drosophila. PNAS 104:222-227, 2007.
Vermeer PD, McHugh J, Rokhlina T, Vermeer DW, Zabner J, and Welsh MJ. Vaccinia Virus Entry, Exit, and Interaction with Differentiated Human Airway Epithelia. J. Virol.,81:9891-9899, 2007.
Ostedgaard LS, Rogers CS, Dong Q, Randak CO, Vermeer DW, Rokhlina T, Karp PH, and Welsh MJ. Processing and Function of CFTR-?F508 Are Species-Dependent. Proc. Natl. Acad. Sci. USA, 104:15370-15375, 2007.
Itani OA, Lamb FS, Melvin JE, and Welsh MJ. Basolateral Chloride current in Human Airway Epithelia. Am. J. Physiol., 293:L991-L999, 2007.
Friese MA, Craner MJ, Etzensperger R, Vergo S, Jemmie JA, Welsh MJ, Vincent A, and Fugger L. Acid-sensing Ion Channel-1 Contributes to Axonal Degeneration in Autoimmune Inflammation of the Central Nervous System. Nature Med. 13(12): 1484-1489. 2007.
Liu, L, Li, Y, Wang, R, Yin, C, Dong, Q, Hing H, Kim C, and Welsh MJ. Drosophila Hygrosensation Requires the TRP Channels Water Witch, Nanchung, and Inactive. Nature, 450(7167):294-298, 2007.
Petroff EY, Price MP, Snitsarev V, Gong H, Korovkina V, Abboud FM, and Welsh MJ. Acid Sensing Ion Channels Interact with and Inhibit BK Channels. Proc. Natl. Acad. Sci. USA, 105(8):3140-3144, 2008.
Shah AS, Farmen SL, Moninger TO, Businga TR, Andrews MP, Bugge K, Searby CC, Nishimura D, Brogden
KA, Kline JN, Sheffied VC, and Welsh MJ. Loss of Badet Biedl Syndrome Proteins Alters the Morphology
and Function of Motile Cilia in Airway Epithelia. Proc. Natl. Acad. Sci. USA, 105(9):3380-3385, 2008.
Sun X, Yan Z, Yalling Y, Ziyi L, Lei D, Rogers CS, Chen J, Welsh MJ, Leno GH, and Engelhardt JF. AAV Targeted Disruption of the CFTR Gene in Cloned Ferrets. J. Clin. Invest., 118(4):1578-1583, 2008.
Rogers CS, Hao Y, Rokhlina T, Samuel M, Stoltz DA, Yi Y, Petroff E, Vermeer DW, Kabel AC, Yan Z, Spate L, Wax D, Murphy CN, Rieke A, Whitworth K, Linville ML, Korte SW, Engelhardt JF, Welsh MJ, and Prather RS. Production of CFTR Null and ?F508 Heterozygous Pigs by AAV-Mediated Gene Targeting and Somatic Cell Nuclear Transfer. J. Clin. Invest., 118(4):1571-1578, 2008.
Ziemann A, Schnizler MK, Albert GW, Severson MA, Howard MA III, Welsh MJ, and Wemmie JA. Seizure Termination by Acidosis depends on ASIC1a. Nat. Neurosci., 11(7):816-822, 2008.
Rogers CS, StoltZ DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray, Jr. PB, Zabner J, Prather RS and Welsh MJ. Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs. Science. 321:1837-1841, 2008.
Eshcol JO, Harding AMS, Hattori T, Costa V, Welsh MJ, and Benson CJ. Acid-sensing Ion Channel 3 (ASIC3) Cell Surface Expression is Modulated by PSSD-95 Within Lipid Rafts. Am. J. Physiol. Cell Physiol., 295(3):C732-739, 2008.
Dong Q, Randak CO, and Welsh MJ. A Mutation in CFTR Modifies the Effects of the Adenylate Kinase Inhibitor Ap5A on Channel Gating, Biophys J, 95(11):5178-5185, 2008.
Schnizler MK, Schnizler K, Zha X, Hall DD, Wemmie JA, Hell JW, and Welsh MJ. The Cytoskeletal Protein a-Actinin Regulates Acid-sensing Ion Channel 1a Through a C-Terminal Interaction. J. Biol. Chem., 284:2697-2705, 2009.
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Howard Hughes Medical Institute |
