Christoph Randak MD Assistant Professor Pediatrics and Neonatology University of Iowa Roy J and Lucille A Carver College of Medicine University of Iowa 500 EMRB Iowa City IA 52242 PHONE: 319 335 6540 FAX: 319 335 7623 christoph-randak@uiowa.edu

Residency/Fellowship
University of München, Germany

Clinical and Research Interests
Dr. Randak's clinical interests include the diagnosis and therapy of infants and children with pulmonary diseases, especially cystic fibrosis (CF). His research focuses on the gene product affected in cystic fibrosis, the cystic fibrosis transmembrane conductance regulator (CFTR) with a major emphasis how CFTR functions and how CF-associated mutations disrupt function. In particular Dr. Randak is interested in how the two nucleotide-binding domains of CFTR regulate CFTR chloride channel activity and how these mechanisms relate to mechanisms in other members of the ATP-binding cassette (ABC) transporter protein familiy, to which CFTR belongs. Dr. Randak investigates CFTR function biochemically and by using patch clamp electrophysiology.

Publications