Welcome to the Tan laboratory in the departments of internal medicine and biomedical engineering at the University of Iowa.
Research
Research in our lab is directed towards understanding gene regulatory networks in normal and disease development. In particular, we would like to gain mechanistic understanding of how genetic and epigenetic factors interact to control gene expression. These efforts will help us better understand how the different processes controlling gene expression are coordinated in the cell and deepen our knowledge of organismal development and disease processes. Towards this overall goal, we are conducting interdisciplinary research that combines wet-lab experiments and computation.
[More about our current research interests...]
Recent Publications
[1] Li Teng, Firpi HA, and Tan K. Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers. 2011. Nucleic Acids Research. [pubmed link]
[2] Ucard D, Hu Q, and Tan K. Combinatorial chromatin modification patterns in the human genome revealed by subspace clustering. 2011. Nucleic Acids Research. 39(10):4063-75. [pubmed link]
[3] Kim J and Tan K. Discover protein complexes in protein-protein interaction networks using parametric local modularity. 2010. BMC Bioinformatics. 11:521. [pubmed link]
[More about our publications...]
