Welcome to the Tan laboratory in the department of internal medicine at the University of Iowa.

Research

Research in our lab is directed towards understanding gene regulatory networks in normal and disease development. In particular, we would like to gain mechanistic understanding of how genetic and epigenetic factors interact to control gene expression. These efforts will help us better understand how the different processes controlling gene expression are coordinated in the cell and deepen our knowledge of organismal development and disease processes. Towards this overall goal, we are conducting interdisciplinary research that combines wet-lab experiments and computation.

[More about our current research interests...]

Recent Publications

[1] Chao Z, Chen C, He B, Tan K and Lu C. A microfluidic device for epigenomic profililng using 100 cells. 2015. Nature Methods. [pubmed link].

[2] Cai X, Gao L, Teng L, Ge J, Oo Z, Kumar AR, Gilliland GD, Mason PJ, Tan K and Speck NA. Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells. 2015. Cell Stem Cell. [pubmed link].

[3] Ma X, Gao L, Karamanlidis G, Gao P, Lee C, Garcia-Menendez L, Tian R, and Tan K. Revealing pathway dynamics in heart diseases by analyzing multiple differential networks. 2015. Plos Computational Biology. [pubmed link].

[More about our publications...]