Welcome to the Tan laboratory in the department of internal medicine at the University of Iowa.

Research

Research in our lab is directed towards understanding gene regulatory networks in normal and disease development. In particular, we would like to gain mechanistic understanding of how genetic and epigenetic factors interact to control gene expression. These efforts will help us better understand how the different processes controlling gene expression are coordinated in the cell and deepen our knowledge of organismal development and disease processes. Towards this overall goal, we are conducting interdisciplinary research that combines wet-lab experiments and computation.

[More about our current research interests...]

Recent Publications

[1] Ma X, Gao L, and Tan K. Modeling disease progression using dynamics of pathway connectivity. 2014. Bioinformatics. [pubmed link].

[2] He B, Chen C, Teng L, and Tan K. Global view of enhancer-promoter interactome in human cells. 2014. Proc. Natl. Acad. Sci. [pubmed link].

[3] Teng L, He B, Gao P, and Tan K. Discover context-specific combinatorial transcription factor interactions by integrating diverse Chip-Seq data sets. 2014. Nucleic Acids Research. 42(4):e24. [pubmed link].

[More about our publications...]