Publications 1996-1999: Links take you to the PubMed listing where many papers can be downloaded free.

1: Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD.
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice.
Physiol Genomics. 1999 Jul 15;1(1):3-9.
2: Mark AL, Shaffer RA, Correia ML, Morgan DA, Sigmund CD, Haynes WG.
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice.
J Hypertens. 1999 Dec;17(12 Pt 2):1949-53.
3: Faraci FM, Sigmund CD.
Vascular biology in genetically altered mice : smaller vessels, bigger insight.
Circ Res. 1999 Dec 3-17;85(12):1214-25. Review.
4: Sinn PL, Davis DR, Sigmund CD.
Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes.
J Biol Chem. 1999 Dec 10;274(50):35785-93.
5: Sinn PL, Zhang X, Sigmund CD.
JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter.
Am J Physiol. 1999 Oct;277(4 Pt 2):F634-42.
6: Shi Q, Black TA, Gross KW, Sigmund CD.
Species-specific differences in positive and negative regulatory elements in the renin gene enhancer.
Circ Res. 1999 Sep 17;85(6):479-88.
7: Lake-Bruse KD, Faraci FM, Shesely EG, Maeda N, Sigmund CD, Heistad DD.
Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice.
Am J Physiol. 1999 Aug;277(2 Pt 2):H770-6.
8: Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD.
Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo.
J Biol Chem. 1999 Jul 23;274(30):21285-90.
9: Sinn PL, Sigmund CD.
Human renin mRNA stability is increased in response to cAMP in Calu-6 cells.
Hypertension. 1999 Mar;33(3):900-5.
10: Yang G, Gray TS, Sigmund CD, Cassell MD.
The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system.
Brain Res. 1999 Jan 30;817(1-2):123-31.
11: Yan Y, Chen R, Pitarresi T, Sigmund CD, Gross KW, Sealey JE, Laragh JH, Catanzaro DF.
Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice.
Circ Res. 1998 Dec 14-28;83(12):1279-88.
12: Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD.
The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes.
Circ Res. 1998 Nov 16;83(10):1047-58.
13: Stec DE, Sigmund CD.
Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system.
Exp Nephrol. 1998 Nov-Dec;6(6):568-75. Review.
14: Yang G, Sigmund CD.
Developmental expression of human angiotensinogen in transgenic mice.
Am J Physiol. 1998 May;274(5 Pt 2):F932-9.
15: Yang G, Sigmund CD.
Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice.
Hypertension. 1998 Mar;31(3):734-40.
16: Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD.
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.
Am J Physiol. 1998 Feb;274(2 Pt 2):H564-70.
17: Merrill DC, Granwehr BP, Davis DR, Sigmund CD.
Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders.
Proc Assoc Am Physicians. 1997 Nov;109(6):533-46. Review.
18: Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD.
The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice.
J Biol Chem. 1997 Oct 31;272(44):28142-8.
19: Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF.
Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells.
Circ Res. 1997 Oct;81(4):558-66.
20: Petrovic N, Kane CM, Sigmund CD, Gross KW.
Downregulation of renin gene expression by interleukin-1.
Hypertension. 1997 Aug;30(2 Pt 1):230-5.
21: Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD.
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.
J Clin Invest. 1997 Mar 15;99(6):1258-64.
22: Ying L, Morris BJ, Sigmund CD.
Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells.
J Biol Chem. 1997 Jan 24;272(4):2412-20.
23: Jones CA, Petrovic N, Novak EK, Swank RT, Sigmund CD, Gross KW.
Biosynthesis of renin in mouse kidney tumor As4.1 cells.
Eur J Biochem. 1997 Jan 15;243(1-2):181-90.
24: Davisson RL, Sigmund CD.
Transgenic animal models as tools for studying renal developmental physiology.
Pediatr Nephrol. 1996 Dec;10(6):798-803. Review.
25: Davisson RL, Nuutinen N, Coleman ST, Sigmund CD.
Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice.
Nucleic Acids Res. 1996 Oct 15;24(20):4023-8.
26: Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW.
Role of proximal promoter elements in regulation of renin gene transcription.
J Biol Chem. 1996 Sep 13;271(37):22499-505.
27: Thompson MW, Smith SB, Sigmund CD.
Regulation of human renin mRNA expression and protein release in transgenic mice.
Hypertension. 1996 Aug;28(2):290-6.
28: Lang JA, Ying LH, Morris BJ, Sigmund CD.
Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells.
Am J Physiol. 1996 Jul;271(1 Pt 2):F94-100.
29: Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD.
Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.
J Clin Invest. 1996 Feb 15;97(4):1047-55.