Henry Keen

Bioinformatics, biological databases, DNA microarrays, development of computational tools for genome analysis, computer simulation of physiological systems, gene-targeted mouse models of human disease.

Bioinformatic Analysis of Gene Sets Regulated by Ligand-Activated and Dominant-Negative Peroxisome Proliferator-Activated Receptor {gamma} in Mouse Aorta.

Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD.

Arterioscler Thromb Vasc Biol. 2009 Dec 17. [Epub ahead of print]

PMID: 20018933

Regulation of renin gene expression by oxidative stress.

Itani H, Liu X, Sarsour EH, Goswami PC, Born E, Keen HL, Sigmund CD.

Hypertension. 2009;53:1070-1076.

PMID: 19433777

Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD.

Endothelium-Specific Interference With Peroxisome Proliferator Activated Receptor Gamma Causes Cerebral Vascular Dysfunction in Response to a High-Fat Diet.

Circ Res. 2008;103:654-661.

PMID: 18676352

Zhou X, Weatherford ET, Liu X, Born E, Keen HL, Sigmund CD.

Dysregulated Human Renin Expression in Transgenic Mice Carrying Truncated Genomic Constructs: Evidence Supporting the Presence of Insulators at the Renin Locus.

Am J Physiol Renal Physiol. 2008;295:F642-653.

PMID: 18632798 [PubMed - as supplied by publisher]

Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD.

Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.

Cell Metab. 2008 Mar;7(3):215-26.

PMID: 18316027 [PubMed - indexed for MEDLINE]

Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM.

Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling.

Hypertension. 2008 Apr;51(4):867-71. Epub 2008 Feb 19. Erratum in: Hypertension. 2008 Apr;51(4):e33.

PMID: 18285614 [PubMed - indexed for MEDLINE]

Weatherford ET, Itani H, Keen HL, Sigmund CD.

Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?

Hypertension. 2007 Nov;50(5):844-6. Epub 2007 Sep 4. No abstract available.

PMID: 17785627 [PubMed - indexed for MEDLINE]

Lavoie JL, Bianco RA, Sakai K, Keen HL, Ryan MJ, Sigmund CD.

Transgenic mice for studies of the renin-angiotensin system in hypertension.

Acta Physiol Scand. 2004 Aug;181(4):571-7. Review.

PMID: 15283772 [PubMed - indexed for MEDLINE]

Keen HL, Ryan MJ, Beyer A, Mathur S, Scheetz TE, Gackle BD, Faraci FM, Casavant TL, Sigmund CD.

Gene expression profiling of potential PPARgamma target genes in mouse aorta.

Physiol Genomics. 2004 Jun 17;18(1):33-42.

PMID: 15054141 [PubMed - indexed for MEDLINE]

Bianco RA, Keen HL, Lavoie JL, Sigmund CD.

Untraditional methods for targeting the kidney in transgenic mice.

Am J Physiol Renal Physiol. 2003 Dec;285(6):F1027-33. Review.

PMID: 14600026 [PubMed - indexed for MEDLINE]

Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD.

Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.

Physiol Genomics. 2002 Dec 3;11(3):253-62.

PMID: 12388794 [PubMed - indexed for MEDLINE]

Stec DE, Keen HL, Sigmund CD.

Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase.

Hypertension. 2002 Feb;39(2 Pt 2):629-33.

PMID: 11882621 [PubMed - indexed for MEDLINE]

Keen HL, Sigmund CD.

Paradoxical regulation of short promoter human renin transgene by angiotensin ii.

Hypertension. 2001 Feb;37(2 Part 2):403-7.

PMID: 11230308 [PubMed - indexed for MEDLINE]