Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?

Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD.

J Biol Chem. 2010 Mar 26;285(13):9311-6. Epub 2010 Feb 3.

PMID: 20129921

 

Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin.

Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD.

Hypertension. 2009 Dec;54(6):1240-7. Epub 2009 Oct 12.

PMID: 19822797