Recent Publications

• Marquez, R.T., Keck, K., Wendlandt, E. and McCaffrey, A.P. microRNA-21 is Upregulated During the Proliferative Phase of Liver Regeneration, Targets Pellino-1 and Inhibits NF-κB Signaling. (American Journal of Physiology-Gastrointestinal and Liver Physiology, Epub ahead of print)
• Cradick, TJ, Kaminsky, P., Keck, K., Jamison, A. and McCaffrey, AP. Zinc-finger Nucleases That Bind and Cut Hepatitis B Virus DNA. (Molecular Therapy, Epub ahead of print)
• Justin P. Dassie, Xiu-ying Liu, Gregory S. Thomas, Ryan M. Whitaker, Kristina Wyatt Thiel, Katie R. Stockdale, David K. Meyerholz, Anton P. McCaffrey, James O. McNamara II, Paloma H. Giangrande (2009) Optimized Aptamer-siRNA Chimeras Lead to Regression of PSMA-expressing Tumors Upon Systemic Administration. Nature Biotechnology 27(9), 839-49.
• McCaffrey AP. RNA interference inhibitors of hepatitis B virus. Ann N Y Acad Sci. 2009 Sep;1175:15-23.
• Keck, K., Volper, E.M., Spengler, R.M., Long, D.D., Chan, C.Y., Ding, Y. and McCaffrey, A.P. (2008) Rational Design Leads to More Potent RNA Interference Against Hepatitis B Virus: Factors Effecting Silencing Efficiency. Molecular Therapy 17(3), 538-47.
• Marquez, R.T. & McCaffrey, A.P. (2008). Advances in MicroRNAs: Implications for Gene Therapists. Human Gene Therapy. 19, 27-38.
• McCaffrey, A.P., Fawcett, P., Nakai, H., McCaffrey, R.L., Ehrhardt, A.,Pham, T.T., Pandey, P., Xu, H., Feuss, S., Storm, T. A., and Kay, M.A. (2008). The Host Response to Adenovirus, Helper Dependent Adenovirus and Adeno-Associated Virus in Mouse Liver. Molecular Therapy. (Molecular Therapy, 16, 931-41).
• Layzer J, McCaffrey AP, Tanner A, Huang Z, Kay M and Sullenger B. (2004). In vivo activity of nuclease-resistant siRNAs. RNA 10:766-771.
• McCaffrey, AP, Nakai, H, Pandey, K, Huang, H, Xu, H, Salazar, FH, Marion, PL and Kay, MA. (2003). Inhibition of Hepatitis B Virus in Mice by RNA Interference. Nat Biotechnol 21:639-644.
• McCaffrey, AP, Meuse, L, Karimi, M and Kay, MA. (2003). Potent Morpholino Antisense Inhibitors of Hepatitis C Internal Ribosome Entry Site Translation in Mice. Hepatology 38:503-508.
• McCaffrey, AP, Meuse, L, Pham TT and Kay, MA. (2002). RNA interference in adult mice. Nature 418:38-39.
• McCaffrey, AP, Ohashi K, Meuse L, Shen S, Lancast A, Lukavsky P, Sarnow P, Kay M. (2002). Determinants of Hepatitis C Translational Initiation in Vitro, In Cultured Cells and Mice. Molecular Therapy 5:676-684.