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Selected Publications

2010

Rodionov RN, Dayoub H, Lynch CM, Wilson KM, Stevens JW, Murry DJ, Kimoto M, Arning E, Bottiglieri T, Cooke JP, Baumbach GL, Faraci FM, Lentz SR. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res. 2010 Feb 19;106(3):551-8.

Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. J Biol Chem. 2010 Feb 19;285(8):5385-91.

DiBello PM, Dayal S, Kaveti S, Zhang D, Kinter M, Lentz SR, Jacobsen DW. The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia. Mol Cell Proteomics. 2010 Mar;9(3):471-85.

Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology. 2010 Mar;51(3):932-41.

2009

Stevens JW, Lentz SR. Countervailing effects on atherogenesis and plaque stability: a paradoxical benefit of hypercoagulability? Circulation. 2009 Sep 1;120(9):722-4.

Raife TJ, Cao W, Atkinson BS, Bedell B, Montgomery RR, Lentz SR, Johnson GF, Zheng XL. Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site. Blood. 2009 Aug 20;114(8):1666-74.

Modrick ML, Didion SP, Lynch CM, Dayal S, Lentz SR, Faraci FM. Role of hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular tone. J Cereb Blood Flow Metab. 2009 Jun;29(6):1130-7.

DiBello PM, Dayal S, Kaveti S, Zhang D, Kinter M, Lentz SR, Jacobsen DW. The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia. Mol Cell Proteomics. 2010 Mar;9(3):471-85.

Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology. 2010 Mar;51(3):932-41.


2008

Rodionov R and Lentz SR. The homocysteine paradox. Arterioscler Thromb Vasc Biol. (2008) Jun;28(6):1031-3

Dayal S, Rodionov RN, Arning E, Bottiglieri T, Kimoto M, Murry DJ, Cooke JP, Faraci FM, Lentz SR. Tissue-specific Downregulation of Dimethylarginine Dimethylaminohydrolase in Hyperhomocysteinemia. Am J Physiol Heart Circ Physiol (2008) Aug;295(2):H816-25.

Dayal S and Lentz SR. Murine Models of Hyperhomocysteinemia and Their Vascular Phenotypes.
Arterioscler Thromb Vasc Biol (2008) Sep;28(9):1596-605.

Dayoub H., Rodionov, R.N., Lynch, C., Cooke, J.P., Arning, E., Bottiglieri, T., Lentz, S.R., and Faraci, F.M. Overexpression of dimethylarginine dimethylaminohydrolase inhibits ADMA-induced endothelial dysfunction in the cerebral circulation. Stroke (2008) 39:180-184

Jobe, S.M., Wilson, K.M., Leo, L., Raimondi, A., Molkentin, J.D., Lentz, S.R., and Di Paola, J. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation. Blood (2008) 111:1257-1265

Chrissobolis, S., Didion, S.P., Kinzenbaw, D.A., Schrader, L.I., Dayal, S., Lentz, S.R., and Faraci, F.M. Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction. Hypertension (in press)

Raife, T.J., Rose, J.S., and Lentz, S.R. Bleeding from acquired coagulation defects and antithrombotic therapy. In: Rossi’s Principles of Transfusion Medicine, 4th ed. (in press)

 

2007

Devlin, A.M., Boersma,H.M., Wade, R.E., Singh, R., Innis, S.M., Bottiglieri T., and Lentz, S.R. Reduced methylation capacity in mice with hyperhomocysteinemia is asssociated with altered hepatic fatty acid and phospholipid metabolism. J. Biol. Chem. (2007) 282:37082-37090

Tsimikas,S., Aikawa,M., Miller, F.J., Jr., Miller, E.R., Torzewski,M., Lentz, S.R., Bergmark, C., Heistad, D.D., Libby, P., and Witzum, J.L. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions following dietary lipid lowering: a potential biomarker of early atherosclerosis regression. Arterioscl. Thromb. Vasc. Biol. (2007) 27:175-181

Wilson, K.M., McCaw, R.B., Leo, L., Arning, E., Lhoták, Š., Bottiglieri, Austin, R.C., and Lentz, S.R. Prothrombotic effects of hypercholesterolemia and hyperhomocysteinemia in ApoE-deficient mice. Arterioscl. Thromb. Vasc. Biol. (2007) 27:233-240

Sontag, E., Nunbhakdi-Craig, V., Sontag, J.M., Diaz-Arrastia, R., Ogris, E., Dayal, S., Lentz, S.R., Arning, E, and Bottiglieri, T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and APP regulation. J. Neurosci. (2007) 27:2751-2759

Kitayama, J., Faraci, F.M., Lentz, S.R., and Heistad, D.D. Cerebral vascular dysfunction during hypercholesterolemia. Stroke (2007) 38:2136-2141

Vitvitsky, V., Prudova, A., Stabler, S., Dayal, S., Lentz, S.R., and Banerjee, R. Testosterone regulation of renal cystathionine β-synthase: implications for sex-dependent differences in plasma homocysteine levels. Am. J. Physiol. Renal Physiol. (2007) 293:F594-600

Lentz, S.R. Homocysteine. In: McGraw-Hill Encyclopedia of Science & Technology, 10th Edition. (2007)

Devlin, A.M. and Lentz, S.R. Hyperhomocysteinemia. In: Clinical Studies in Medical Biochemistry, 3rd Edition. Glew, R.H. and Rosenthal, M.D., editors. Oxford University Press (2007) 226-233

Dayal, S. and Lentz, S.R. Role of redox reactions in the vascular phenotype of hyperhomocysteinemic animals. Antioxid. Redox Signal. (2007) 9:1899-1909

 

2006

Devlin, A.M. and Lentz, S.R. Apo A-I: a missing link between homocysteine and lipid metabolism? Circ. Res. (2006) 98:431-433

Dayal, S., Wilson, K.M., Leo, L., Arning, E., Bottigliere, T., and Lentz, S.R. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood. (2006); 108:2237-2243. 

Symons, J.D., Zaid, U.B., Athanassious, C.N., Mullick, A.E., Lentz, S.R., and Rutledge, J.C. Influence of folate on arterial permeability and stiffness in the absence or presence of hyperhomocysteinemia. Arterioscl. Thromb. Vasc. Biol. (2006) 26:814-818

Fernández, J.A., Lentz, S.R., Dwyre, D.M., and Griffin, J.H. A novel ELISA for mouse activated protein C. J. Immunol. Method. (2006) 314:174-181

Mullick, A.E., Zaid, U.B., Athanassious, C.N., Lentz, S.R., Rutledge, J.C., and Symons, J.D. Hyperhomocysteinemia increases arterial permeability and stiffness in mice. Am. J. Physiol. (2006) 291:R1349-R1354

2005

Devlin, A.M., Bottiglieri, T., Domann, F.E., and Lentz, S.R. Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J. Biol. Chem. (2005) 280:25506-25511

Dayal, S., Devlin, A.M., McCaw, R.B., Liu, M.L., Arning, E., Bottiglieri, T., Shane, B., Faraci, F.M., and Lentz, S.R. Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation (2005) 112:737-744

Jobe, S.M., Leo, L., Eastvold, J., Dickneite, G., Ratliff, T.L., Lentz, S.R., and Di Paola, J. Role of FcRγ and factor XIIIA in coated platelet formation. Blood (2005) 106:4146-4151

Wilson, K.M. and Lentz, S.R. Need for mechanical ventilation with murine thrombosis models (Letter). Thromb. Haemost. (2005) 93:389

Lentz, S.R. Another lesson from the factor V Leiden mouse: thrombin generation drives arterial disease. Circulation (2005) 111:1733-1734

Raife, T.J. and Lentz, S.R. The benefits of excess EPCR. J. Thromb. Haemost. (2005) 3:1349-1350

Lentz, S.R. Mechanisms of homocysteine-induced atherothrombosis. J. Thromb. Haemost. (2005) 3:1646-1654

Wilson, K.M. and Lentz, S.R. Mechanisms of the atherogenic effects of elevated homocysteine in experimental models. Sem. Vasc. Med. (2005) 5: 163-171

Dayal, S. and Lentz, S.R. ADMA and hyperhomocysteinemia. Vascular Medicine (2005) 10:S27-33

Lentz, S.R., Devlin, A.M., and Dayal, S. Endothelial dysfunction & homocysteine: studies in genetic models of moderate hyperhomocysteinemia in mice. (2005) In: Homocysteine Metabolism. Symposia Proceedings, 4th International Conference on Homocysteine Metabolism. Fowler, B. Ed. SPS Publications

2004

Dayal, S., Arning, E., Bottiglieri, T., Böger, R.H., Sigmund, C.D., Faraci, F.M., and Lentz, S.R. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke (2004) 35: 1957-1962

Devlin, A.M., Arning, E., Bottiglieri, T., Faraci, F.M., Rozen, R., and Lentz, S.R. Effect of MTHFR genotype on diet-induced hyperhomocysteinemia and vascular dysfunction in mice. Blood (2004) 103:2624-2629

Crist, S.A., Elzey, B.D., Ludwig, A.T., Griffith, T.S., Staack, J.B., Lentz, S.R., and Ratliff, T.L. Expression of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets. Exp. Hematol. (2004) 32:1073-1081

Vitvitsky, V., Dayal, S., Stabler, S., Wang, H., Lentz, S.R., and Banerjee, R. Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am. J. Physiol. (2004) 287:R39-R46

Zhou, J., Werstuck, G.H., Lhoták, Š., de Koning, A.B.L., Sood, S.K., Hossain, G.S., Møller, J., Ritskes-Hoitinga, M., Falk, E., Dayal, S., Lentz, S.R., and Austin, R.C. Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apoE-deficient mice. Circulation (2004) 110:207-213

Lentz, S.R. and Haynes, W.G. Homocysteine: a clinically important cardiovascular risk factor? Cleveland Clinic J. Med. (2004) 71:729-734

Austin, R.C., Lentz, S.R., and Werstuck, G.H. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Diff. (2004) 11:S56-S64

2003

Lentz, S.R.  Thrombosis of vein grafts: wall tension restrains thrombomodulin expression. Circ. Res. 2003 Jan 10;92(1):12-3

Lentz, S.R. Homocysteine. In: McGraw-Hill Yearbook of Science & Technology. McGraw-Hill Companies, New York. (2003) 180-182

Slungaard, A., Fernández, J.A., Griffin, J.H., Key, N.L., Long, J.L., Piegors, D.J., and Lentz, S.R. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood, 2003; 102: 146-151.

Elzey, B.D., Tian, J., Jensen, R.J., Swanson, A.K., Lees, J.R., Lentz, S.R., Stein, C., Nieswandt, B., Wang, Y., Davidson, B., and Ratliff, T.L. Platelet-mediated modulation of adaptive immunity: a communication link between innate and adaptive immune compartments. Immunity (2003) 19:9-19.

Wilson, K.M., Lynch, C.M., Faraci, F.M., and Lentz, S.R. Effect of mechanical ventilation on carotid artery thrombosis induced by photochemical injury in mice. J. Thromb. Haemost. (2003) 1:2669-2674.

Lentz, S.R., Rodionov, R.N., and Dayal, S. Hyperhomocysteinemia, endothelial dysfunction, and cardiovascular risk: the potential role of ADMA. Atherosclerosis (2003) Suppl. 4, 61-65.

Faraci, F.M. and Lentz, S.R. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke (2004) 35:345-347

2002

Raife, T.J., Lentz, S.R., Atkinson, B., Vesely, S.K., and Hessner, M.J. Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity. Blood (2002) 99:437-442

Rosenfeld, S.B., Watkinson, K.K., Thompson, B.H., Macfarlane, D.E., and Lentz, S.R. Pulmonary embolism after sequential use of recombinant factor VIIa and activated prothrombin complex concentrate in a factor VIII inhibitor patient. Thromb. Haemost. (2002) 87:925-926

Lentz, S.R., Miller, F.J., Jr., Piegors, D.J., Erger, R.A., Fernández, J.A., Griffin, J.H., and Heistad, D.D. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation (2002) 106:842-846

Lentz, S.R., Piegors, D.J., Fernández, J.A., Erger, R.A., Arning, E., Malinow, M.R., Griffin, J.H., Bottiglieri, T., Haynes, W.G., and Heistad, D.D. Effect of hyperhomocysteinemia on protein C activation and activity. Blood (2002) 100:2108-2112

Leo, L., Di Paola, J., Judd, B.A., Koretzky, G.A., and Lentz, S.R. Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen. Blood (2002) 100:2839-2844

Baumbach, G.L., Sigmund, C.D., Bottiglieri, T., Arning, E., and Lentz, S.R. Structure of cerebral arterioles in cystathionine b-synthase-deficient mice. Circ. Res. (2002) 91:931-937

Dayal, S., Brown, K.L, Weydert, C.J., Oberley, L.W., Arling, E., Bottiglieri, T., Faraci, F.M., and Lentz, S.R. Deficiency of glutathione peroxidase-1 sensitizes to endothelial dysfunction in hyperhomocysteinemic mice. Arterioscler. Thromb. Vasc. Biol. (2002) 22:1996-2002.

Raife, T.J., Rosenfeld, S.B., and Lentz, S.R. Bleeding from acquired coagulation defects and fibrinolytic therapy. In: Rossi’s Principles of Transfusion Medicine, 3rd ed. Simon, T.L., Dzik, W.H., Snyder, E., Stowell, C.P., and Strauss, R.G., editors. R.G. Lippincott Williams & Wilkens, Philadelphia. (2002) 399-414

Lentz, S.R. ATVB In Focus: a new series of focused brief reviews in Arteriosclerosis, Thrombosis, & Vascular Biology. Arterioscler. Thromb. Vasc. Biol. (2002) 22:1064

Hiatt, B.K and Lentz, S. R. Prothrombotic states that predispose to stroke. Current Treatment Options in Neurology (2002) 4:417-425

2001

Böger, R.H., Lentz, S.R., Bode-Böger, S.M., Knapp, H.R., and Haynes, W.G. Elevation of asymmetric dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inemia in humans. Clin. Sci. (2001) 100:161-167

Lentz, S. R. Piegors, D.J., Malinow, M.R., and Heistad, D.D. Supplementation of atherogenic diet with B vitamins does not prevent atherosclerosis or vascular dysfunction in monkeys. Circulation (2001) 103:1006-1011

Werstuck, G.H., Lentz, S.R., Dayal, S., Hossain, G.S., Sood, S.K., Shi, Y.Y., Zhou, J., Maeda, N., Krisans, S.K., Malinow, M.R., and Austin, R.C. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and fatty acid biosynthesis pathways. J. Clin. Invest. (2001) 107:1263-1273

Dayal, S., Bottiglieri, T., Arning, E., Maeda, N., Malinow, M.R., Sigmund, C.D., Heistad, D.D., Faraci, F.M., and Lentz, S.R. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine b-synthase-deficient mice. Circ. Res. (2001) 88:1203-1209

Piette, W.W. and Lentz, S.R. Endothelial protein C activation in meningococcal sepsis (Letter). N. Eng. J. Med. (2001) 345:1776

Lentz, S.R. Homocysteine and cardiovascular physiology. In: Homocysteine in Health and Disease. Carmel, R. and Jacobsen, D.W., editors. R.G. Cambridge University Press, New York. (2001) 441-450.

Lentz, S.R. Does homocysteine promote atherosclerosis? Arterioscler. Thromb. Vasc. Biol. (2001) 21:1385-1386

2000

Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.

Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.

Böger, R.H., Bode-Böger, S.M., Heistad, D.D., Frolich, J.C. and Lentz, S.R. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia. Arterioscler. Thromb. Vasc. Biol. (2000) 20:1557-1564

Mudd, S.H, Finkelstein, J.D., Refsum, H., Ueland, P.M., Lentz, S.R., Jacobsen, D.W., Brattström, L., Wilcken, B., Wilcken, D.E.L., Blom, H.J., Stabler, S.P., Allen, R.H., Selhub, J., and Rosenberg, I.H. Homocysteine and its disulfide derivatives: a suggested consensus terminology. Arterioscler. Thromb. Vasc. Biol. (2000) 20:1704-1706

Lentz, S.R., Erger, R.A., Dayal, S., Maeda, N., Malinow, M.R., Heistad, D.D., and Faraci, F.M. Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine b -synthase-deficient mice. Am. J. Physiol. Heart Circ. Physiol. (2000) 279:H970-H975

Joyce, D.E, Piette, W.W., Stone, M.S., Carlisle, T.L., and Lentz, S.R. Severe acquired protein S deficiency and skin necrosis in a patient with ANCA-associated vasculitis. Thromb. Haemost. (2000) 84:929-930

Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.

Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 2000 ed.

Shrader, M. and Lentz, S.R. Electronic communication at Arteriosclerosis, Thrombosis, and Vascular Biology. Arterioscler. Thromb. Vasc. Biol. (2000) 20:1851

1990-1999

Clements, J.L., Lee, J.R., Yang, B., Olson, J.D., Sandra, A., Lentz, S.R., and Koretzky,G.A. Fetal hemorrhage and platelet dysfunction in SLP-76 deficient mice. J. Clin. Invest. (1999) 103:19-25

Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1999 ed.

Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1999 ed.

Lentz, S.R., Fernandez, J.A., Griffin, J.H., Piegors, D.J., Erger, R.A., J.A., Malinow, M.R., and Heistad, D.D. Impaired anticoagulant response to infusion of thrombin in atherosclerotic monkeys associated with acquired defects in the protein C system. Arterioscler. Thromb. Vasc. Biol. (1999) 19:1744-1750

Peterson, J.J., Rayburn, H.B., Lager, D.J., Raife, T.J., Kealey, G.P., Rosenberg, R.D., and Lentz, S.R. Expression of thrombomodulin and consequences of thrombomodulin deficiency during healing of cutaneous wounds. Am. J. Pathol. (1999) 155:1569-1575

Raife, T.J., Lager, D.J., Peterson, J.J., Erger, R.A., and Lentz, S.R. Keratinocyte-specific expression of human thrombomodulin in transgenic mice. Effects on epidermal differentiation and cutaneous wound healing. (1998) J. Investigat. Med. 46:127-133

Lentz, S.R. Hyperhomocysteinemia. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1998

Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1998 ed.

Raife, T. J., McArthur, J., Peters, C., Kisker, C. T., and Lentz, S.R. Remission after 13-cis retinoic acid treatment in a case of refractory thrombotic thrombocytopenic purpura. Lancet (1998) 352:454-455

Lentz, S.R. Mechanisms of thrombosis in hyperhomocysteinemia. (1998) Current Opinion in Hematology 5:343-349

Raife, T. J., Olson, J.D, and Lentz, S.R. Platelet antibody testing in idiopathic thrombocytopenic purpura. (1997) Blood 89:1112-1113

Joyce, D.E., Chen, Y., Erger, R.A., Koretzky, G.A., and Lentz, S.R. Functional interactions between the thrombin receptor and the T cell antigen receptor in human T cell lines. (1997) Blood 90:1893-1901

Lentz, S.R., Malinow, M.R., Piegors, D.J., Bhopatkar-Teredesai, M., Faraci, F.M., and Heistad, D.D. Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys. Arterioscler. Thromb. Vasc. Biol. (1997) 17:2930-2934

Heistad, D.D, Lentz, S.R., Hayreh, S.S., and Faraci, F.M. Cerebral vascular effects of atherosclerosis and homocysteine: potential target for gene therapy. In: Proceedings of the 20th Princeton Conference. Futura. (1997)

Lentz, S.R. Hypercoagulable states and cerebrovascular disease. In: Neurobase. Gilman, S., Goldstein, G.W, and Waxman, S.G., editors. Arbor Publishing Corp, La Jolla, CA, 1997 ed.

Lentz, S.R. Homocysteine and vascular dysfunction. (1997) Life Sciences 61:1205-1215

Schlueter, A.J., Al-Jurf, A.S., and Lentz, S.R. Kung fu phlebitis: an unusual presentation of Mondor's disease. (1996) Am. J. Hematol. 52:66-67

Lentz, S.R., Sobey, C.G., Piegors, D.J., Bhopatkar, M.Y., Faraci, F.M., Malinow, M.R., and Heistad, D.D. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. (1996) J. Clin. Invest. 98:24-29

Raife, T.J., Demetroulis, E.M., and Lentz, S.R. Regulation of thrombomodulin expression by all-trans retinoic acid and tumor necrosis factor-a : differential responses in keratinocytes and endothelial cells. (1996) Blood 88:2043-2049

Newell, A.A, Raife, T.J., and Lentz, S.R. Interference in protein C activation assays from endogenous serpins in mammalian host cells. (1996) Thromb. Res. 84:373-377

Heistad, D.D, Lentz, S.R., and Rios, C.D. Atherosclerotic vascular disease: will folate or gene therapy be useful? Trans. Am. Clin. Climatol. Assoc. (1996) 108:69-77

Lager, D.J., Callaghan, E.J., Worth, S.F., Raife, T.J., and Lentz, S.R. Cellular localization of thrombomodulin in human epithelium and squamous malignancies. (1995) Am. J. Pathol. 146:933-943

Raife, T.J., Lager, D.J., Madison, K.C., Piette, W.W., Howard, E.J., Sturm, M.T., Chen, Y. and Lentz, S.R. Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation. (1994) J. Clin. Invest. 93:1846-1851

Lentz, S.R. and Sadler, J.E. The molecular basis of thrombomodulin function. In: Thrombin, thrombomodulin, and the control of hemostasis. Giddings, J.C., editor. R.G. Landes Company, Austin, TX. (1994) 91-120

Lentz, S.R., Krewson, L, and Zutter, M.M. Recurrent neuroendocrine (Merkel cell) carcinoma of the skin presenting as marrow failure in a man with systemic lupus erythematosus. (1993) Med. Pediatr. Oncol. 21:137-141

Lentz, S.R. and Sadler, J.E. Homocysteine inhibits von Willebrand factor processing and secretion by preventing transport from the endoplasmic reticulum. (1993) Blood 81:683-689

Lentz, S.R., Chen. Y., and Sadler, J.E. Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin. (1993) J. Biol. Chem. 268:15312-15317

Sadler, J.E., Lentz, S.R., Sheehan, J.P., Tsiang, M., Wu, Q. Structure-function relationships of the thrombin-thrombomodulin interaction. (1993) Haemostasis 23
(suppl 1):183-193

Tsiang, M., Lentz, S.R., and Sadler, J.E. Functional domains of membrane-bound human thrombomodulin: EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity. (1992) J. Biol. Chem. 267:6164-6170

Wu, Q., Tsiang, M., Lentz, S.R., and Sadler, J.E. Ligand specificity of human thrombomodulin: equilibrium binding of human thrombin, meizothrombin and factor Xa to recombinant thrombomodulin. (1992) J. Biol. Chem. 267:7083-7088

Lentz, S.R. Disorders of hemostasis. In: Manual of Medical Therapeutics, 27th ed. Woodley, M. and Whelan, A., editors. Little, Brown and Company, Boston. (1992) 323-340

Lentz, S.R., Tsiang, M., and Sadler, J.E. Regulation of thrombomodulin by tumor necrosis factor-a : comparison of transcriptional and posttranscriptional mechanisms. (1991) Blood 77:542-550

Wu, Q., Sheehan, J.P., Tsiang, M., Lentz, S.R., Birktoft, J.J., and Sadler, J.E. Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin. (1991) Proc. Natl. Acad. Sci. USA 88:6775-6779

Lentz, S.R. and Sadler, J.E. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. (1991) J. Clin. Invest. 88:1906-1914

Lentz, S.R., Raish, R.J., Orlowski, E.P., and Marion, J.M. Squamous cell carcinoma in epidermolysis bullosa: treatment with systemic chemotherapy. (1990) Cancer 66:1276-1278

Tsiang, M., Lentz, S.R., Dittman, W.A., Wen, D., Scarpati, E.M., and Sadler, J.E. Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues. (1990) Biochemistry 29:10602-10612