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Basic Science

Buño W, Bonansco C, González-Alegre P, González de la Vega A, García-Segura LM. Tetanic stimulation of Schaffer collaterals induces rhythmic bursts via NMDA receptor activation in rat CA1 pyramidal neurons. Hippocampus 2002;12:434-446.

Gonzalez-Alegre P, Miller VM, Davidson B, Paulson H. Toward therapy for DYT1 dystonia: Allele-specific silencing of mutant torsinA. Annals of Neurology 2003. Annals of Neurology 2003;53:781-787.  

Gonzalez-Alegre P, Paulson HL. Aberrant cellular behavior of mutant TorsinA implicates nuclear envelope dysfunction in DYT1 dystonia. J Neuroscience 2004;24(11):2593-2601.  

Gonzalez-Alegre P, Bode N, Davidson BL, Paulson HP. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1. J Neuroscience 2005;25: 10502-10509.  

 

Miller VM, Paulson HL, Gonzalez-Alegre P. RNA interference in neuroscience: progress and challenges. Cellular and Molecular Neurobiology 2005;25(8):1195-1207.  

 

Rodriguez-Lebron E, Gonzalez-Alegre P. Silencing neurodegenerative disease: bringing RNA interference to the clinic. Expert Review of Neurotherapeutics 2006;6(2):223-233.

Gonzalez-Alegre P. Therapeutic RNA interference for neurodegenerative diseases: from promise to progress. Pharmacol Ther. 

Paulson H, Gonzalez-Alegre P. RNAi gets its prize. Lancet Neurol 2006;5:997-9. 

Gonzalez-Alegre P, Paulson HL. Technology insight: therapeutic RNA interference--how far from the neurology clinic? Nat Clin Pract Neurol. 2007 Jul;3(7):394-404.

Harper SQ, Gonzalez-Alegre P. Lentivirus-mediated RNA interference in mammalian neurons. Methods Mol Biol. 2008;442:95-112.

Gordon KL, Gonzalez-Alegre P. Consequences of the DYT1 mutation on torsinA oligomerization and degradation. Neuroscience. 2008 Dec 2;157(3):588-95. Epub 2008 Sep 27.

Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF, El-Shanti HI. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet. 2008 Nov;83(5):572-81. Epub 2008 Oct 30.

González-Alegre P. [Therapeutic RNA interference for neurodegenerative diseases] Rev Neurol. 2008 Dec 16-31;47(12):641-7.

Martin JN, Bair TB, Bode N, Dauer WT, Gonzalez-Alegre P. Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia. Neuroscience. 2009 Aug 5

Clinical Science

Sanchez Chaparro MA, Merida de la Torre FJ, Gonzalez Alegre P, Gonzalez Santos P. Transverse myelitis caused by Brucella. Rev Clin Esp 1999 Nov; 199 (11):778.  

 

Gonzalez-Alegre P, Ruiz-Lopez AD, Abarca-Costalago M, Gonzalez-Santos P. Increment of the Platelet Count in Temporal Arteritis: Response to Therapy and Ischemic Complications. Eur Neurol 2001 Jan;45(1):43-45.  

 

Gonzalez-Alegre P, Recober A, Kelkar P. Idiopathic Brachial Neuritis. Iowa Orthop J 2002; 22:81-85.  

 

Gonzalez-Alegre P, Tippin J. Prolonged cortical electrical depression and diffuse vasospasm without ischemia in a case of severe hemiplegic migraine during pregnancy. Headache 2003;43:72-75.  

 

Gonzalez-Alegre P, Ammache Z, Davis PH, Rodnitzky R. Moyamoya-induced paroxysmal dyskinesia. Mov Disord 2003;18(9):1051-1056.  

 

Gonzalez-Alegre  P. Severe interscapular pain and elevated creatine kinase: the answer was in the ankles. Emerg Med J 2005;22:148-155.  

 

Gonzalez-Alegre P, Afifi AK. Clinical Characteristics of Childhood - Onset  (Juvenile) Huntington's Disease. Report of Twelve Patients and Review of the Literature. Journal of Child Neurology 2006;21(3):223-229.  

 

Jinnah HA, Visser JE, Harris JC, Verdu A, Larovere L, Ceballos-Picot I, Gonzalez-Alegre P, Neychev V, Torres RJ, Dulac O, Desguerre I,  Schretlen DJ, Robey KJ, Barabas G, Bloem BR, Nyhan W, Kremer R, Eddey GE, Puig JG, Reich SG. Delineation of the Motor Disorder of Lesch-Nyhan Disease. Brain 2006;129:1201-17  

 

Gonzalez-Alegre P, Kelkar P, Rodnitzky RL. Isolated high frequency jaw tremor relieved by botulinum toxin injections. Mov Disord 2006;21(7):1049-50.  

 

Gonzalez-Alegre P. Monomelic Parkinsoniam Tremor Caused by Contralateral Substantia Nigra Stroke. Parkinsonism Relat Disord. Published online May 26 2006.

 

Gonzalez-Alegre P. The inherited dystonias. Semin Neurol. 2007 Apr;27(2):151-8

 

Harlow TL, Rodnitzky RL, Gonzalez-Alegre P. From essential tremor to Klinefelter through Fragile X, an unexpected journey. Pharmacol Ther. 2007 Apr;114(1):34-55. Epub 2007 Jan 25. Mov Disord. 2008 Jul 15;23(9):1328-9.

 

Harlow TL, Gonzalez-Alegre P. High prevalence of reported tremor in Klinefelter syndrome. Parkinsonism Relat Disord. 2009 Jun;15(5):393-5. Epub 2008 Nov 5.