Publications 2009

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy.
Chen YH, Chang M, Davidson BL.
Nat Med. 2009 Oct;15(10):1215-8. (Epub 2009 Sep 13) (Abstract) (pdf)
Comment in:
Gateway to the diseased brain.
Mingozzi F, High KA.
Nat Med. 2009 Oct;15(10):1123-4. (Abstract)

Large-scale analysis of exonized mammalian-wide interspersed repeats (MIRs) in primate genomes.
Lin L, Jiang P, Shen S, Sato S, Davidson BL, Xing Y.
Hum Mol Genet. 2009 Mar 26. (Abstract)

Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice.
Boudreau RL, McBride JL, Martins I, Shen S, Xing Y, Carter BJ, Davidson BL.
Mol Ther. 2009 Feb 24. (Abstract) (pdf)

Publications 2008

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi.
McBride JL, Boudreau RL, Harper SQ, Staber PD, Monteys AM, Martins I, Gilmore BL, Burstein H, Peluso RW, Polisky B, Carter BJ, Davidson BL.
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5868-73. (Abstract)

Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis.
Chang M, Cooper JD, Sleat DE, Cheng SH, Dodge JC, Passini MA, Lobel P, Davidson BL.
Mol Ther. 2008 Apr;16(4):649-56. (Abstract) (pdf)

Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs.
Boudreau RL, Monteys AM, Davidson BL.
RNA. 2008 Sep;14(9):1834-44. (Abstract)

Diverse splicing patterns of exonized Alu elements in human tissues.
Lin L, Shen S, Tye A, Cai JJ, Jiang P, Davidson BL, Xing Y.
PLoS Genet. 2008 Oct 17;4(10):e1000225. (Abstract)

Artificial MicroRNAs as siRNA Shuttles: Improved Safety as Compared to shRNAs In vitro and In vivo.
Boudreau RL, Martins I, Davidson BL.
Mol Ther. 2008 Nov 11. (Abstract) (pdf)

Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses.
Coryell MW, Wunsch AM, Haenfler JM, Allen JE, McBride JL, Davidson BL, Wemmie JA.
J Neurosci. 2008 Dec 17;28(51):13738-41. (Abstract)

The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.
Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL.
J Neurosci. 2008 Dec 31;28(53):14341-6. (Abstract)