Publications 2007-present

Munroe, M.E. and Bishop, G.A.  A costimulatory function for T cell CD40.  J. Immunol. 178:671-682, 2007.


Munroe, M.E., Arbiser, J.L. and Bishop, G.A.  Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis.  J. Immunol. 179:753-763, 2007.


Xie, P., Stunz, L.L., Larison, K.D., Yang, B. and Bishop, G.A.  TRAF3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.  Immunity 27:253-267, 2007.


Rahhal, R., VandenBush, T.J., McLendon, M.K., Apicella, M.A. and Bishop, G.A.  Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes.  J. Leuk. Biol. 82:813-820, 2007


Rowland, S.L., Tremblay, M.M., Ellison, J.M., Stunz, L.L., Bishop, G.A. and Hostager, B.S.  A novel mechanism for TRAF6-dependent CD40 signaling.  J. Immunol. 179:4645-4653, 2007. 


Bishop, G.A. and Xie, P.  Multiple roles of TRAF3 signaling in lymphocyte function.  Immunol. Res. 39:22-32, 2007.


Bishop, G.A., Moore, C.R., Xie, P., Stunz, L.L. and Kraus, Z.J.  TRAF proteins in CD40 signaling.  Adv. Exp. Med. Biol. 597:131-151, 2007.

VandenBush, T.J. and Bishop, G.A.  TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation.  Eur. J. Immunol. 38:400-409, 2008.


Xie, P., Kraus, Z.J., Stunz, L.L. and Bishop, G.A.  Roles of TRAF molecules in B lymphocyte function.  Cytokine & Growth Factor Reviews 19:199-207, 2008.


Peters, A.L., Plenge, R., Graham, R., Altshuler, D., Moser, K., Gaffney, P.M. and Bishop, G.A.  A novel polymorphism of the human CD40 receptor with enhanced function.  Blood 112:1863-1871, 2008.


Xue, H., Jing, X., Zhao, D., Haring, J.S., Bollenbacher-Reilley, J., Yang, B., Liu, C., Bishop, G.A., Harty, J.T. and Leonard, W.J.  Targeting the GABPb1L  isoforms does not perturb lymphocyte development and function.  Mol. Cell Biol. 28:4300-4309, 2008. 


Kraus, Z.J., Haring, J.S. and Bishop, G.A.  TRAF5 is required for optimal T cell expansion and survival in response to infection.  J. Immunol. 181:7800-7809, 2008.


Hildebrand, J., Xie, P. and Bishop, G.A.  Signal transduction by receptors for BAFF and APRIL.  In Blys Ligands and Receptors, M. Cancro, Ed., Humana Press, Totowa, NJ.  Chapter 5, p. 93-114, 2009. 


Graham, J.P., Moore, C.R. and Bishop, G.A.  Roles of the TRAF2/3 binding site in differential B cell signaling by CD40 and its viral oncogenic mimic, LMP1. J. Immunol. 183:2966-2973, 2009. 


Poovassery, J.S., Vanden Bush, T.J., and Bishop, G.A.  Antigen receptor signals rescue B cells from TLR tolerance.  J. Immunol. 183:2974-2983, 2009.


Peters, A.L., Stunz, L.L. and Bishop, G.A.  CD40 and autoimmunity: The dark side of a great activator.  Seminars in Immunol. (G.A. Bishop, Guest Editor) 21:293-300, 2009.


Kraus, Z.J., Nakano, H. and Bishop, G.A.  TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40.  Proc. Natl. Acad. Sci. (USA) 106:17140-17145,     2009.


Vanden Bush, T.J., Buchta, C.M., Claudio, J. and Bishop, G.A.  Cutting Edge: Importance of IL-6 and cooperation between innate and adaptive immune receptors in cellular vaccination with B lymphocytes.  J.            Immunol. 183:4833-4837, 2009.


Tseng, W., Lu, J., Bishop, G.A., Watson, A.D., Sage, A.P., Demer, L., and Tintut, Y.  Regulation of IL-6 expression in osteoblasts by oxidized phospholipids.  J. Lipid. Res. 51:1010-1016, 2010.


Graham, J.P., Arcipowski, K.M. and Bishop, G.A.   Differential B lymphocyte regulation by CD40 and its viral mimic, LMP1.  Immunological Reviews 237:226-248, 2010. 


Peters, A.L., Stunz, L.L., Meyerholz, D.K., Mohan, C. and Bishop, G.A.  LMP1, the EBV-encoded oncogenic mimic of CD40, accelerates autoimmunity in B6.Sle mice. J. Immunol. 185:4053-4062, 2010.


Munroe, M.E., Businga, T.E., Kline, J.N. and Bishop, G.A.  Anti-inflammatory effects of the neurotransmitter agonist Honokiol, in a mouse model of asthma.  J. Immunol. 185:5586-5597, 2010.


Hildebrand, J.M., Luo, Z. Manske, M.K., Price-Troska, T., Ziesmer, S.C., Lin, W., Hostager, B.S., Slager, S., Witzig, T.E., Ansell, S.M., Cerhan, J.R., Bishop, G.A.* and Novak, A.J.* (*co-senior authors).  A BAFF-R mutation associated with non-Hodgkin lymphoma exhibits altered TRAF recruitment and reveals new insights into proximal BAFF-R signaling.  J. Exp. Med. 207:2569-2579, 2010.


Peters, A.L. and Bishop, G.A.  Differential TRAF3 utilization by a variant human CD40 with enhanced signaling.  J. Immunol. 185:6555-6562, 2010.


Xie, P., Kraus, Z.J., Stunz, L.L., Liu, Y. and Bishop, G.A.  TRAF3 is required for T cell-mediated immunity and TCR/CD28 signaling.  J. Immunol. 186:143-155, 2011.


Decker, D.A., Hostager, B.S. and Bishop, G.A.  CD40 signaling.  Chapter for Encyclopedia of Signaling Molecules, Sangdun Choi, Editor, Springer Press.  2011.


Arcipowski, K.M., Stunz, L.L., Graham, J.P., Kraus, Z.J., Vanden Bush, T.J. and Bishop, G.A. Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1). J. Biol. Chem. 286:9948-9955, 2011. 


Vanden Bush, T.J. and Bishop, G.A. CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation. PLoS One 6(4): e19468. doi:10.1371/journal.pone.0019468, 2011.


Hildebrand, J.M., Yi, Z., Buchta, C.M., Poovassery, J., Stunz, L.L. and Bishop, G.A.  TRAF3 and TRAF5 in immune regulation.   Invited review for Immunological Reviews 244:55-74, 2011.


Xie, P., Poovassery, J., Stunz, L.L., Smith, S.M., Schultz, M.L., Carlin, L.C. and Bishop, G.A.  Enhanced TLR responses of TRAF3-deficient B lymphocytes.  J. Leuk. Biol. 90: 1149-1157, 2011.


Bishop, G.A. The power of mAbs as agents of discovery: CD40 revealed as a B lymphocyte costimulator.  Invited “Pillars of Immunology” article for The Journal of Immunology 188:4127-4129, 2012. 


Poovassery, J. and Bishop, G.A.  Type I interferon and the BCR regulate TLR7 responses by distinct molecular mechanisms.  J. Immunol. 189:1757-1764, 2012. 


Arcipowski, K.M. and Bishop, G.A.  Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1.  PLoS One, 7(7) e42478, 2012.


Arcipowski, K.M. and Bishop, G.A. TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1. J. Immunol. 189:5165-5170, 2012.


Bishop, G.A. The power of mAbs as agents of discovery: CD40 revealed as a B lymphocyte costimulator.  Invited “Pillars of Immunology” article for The Journal of Immunology 188:4127-4129, 2012. 


Arcipowski, K.M. and Bishop, G.A.  TRAF6 as a critical regulator of B lymphocyte functions.  Invited review for Current Topics in Immunology, in press, 2013.


Bishop, G.A. The many faces of TRAF molecules in immune regulation.  AAI Presidential Address.  J. Immunol. 191:3483-3485, 2013.


Yi, Z., Stunz, L.L. and Bishop, G.A. TRAF3 plays a key role in the development and function of invariant Natural Killer T cells.  J. Exp. Med., 210:1079-1086, 2013.


Han, S., Tompkins, V., Son, D., Kamberos, D.O., Stunz, L.L., Halwani, A., Bishop, G.A. and Janz, S.  Piperlongumine inhibits proliferation and survival of LMP1/MYC-induced mouse B lymphoma cells.  Biochem. Biophys. Res. Comm. 436:660-665,  2013. 


Arcipowski, K.M., Stunz, L.L. and Bishop, G.A. TRAF6 is a critical regulator of LMP1 functions in vivo.  Int. Immunol., in press, 2013.


Miletic, A.V., Jellusova, J., Cato, M.H., Lin, W.W., Hu, Y., Bishop, G.A., Shlomchik, M.J. and Rickert, R.C.  Context-specific BAFF-R signaling by the NF-kB and PI3K pathways.  Cell Reports 5:1022-1035, 2013.

Hostager, B.S. and Bishop, G.A. CD40-mediated activation of the NF-kB2 pathway.  Frontiers in Immunology (Inflammation) 4:Article 376, Nov. 2013.


 Lin, W.W., Hildebrand, J.M. and Bishop, G.A. A complex relationship between TRAF3 and non-canonical NF-kB2 activation in B lymphocytes.  Front. Immunol. (Inflammation), 4:477, Dec 2013.


Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ. TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development, Proc Natl Acad Sci USA. 110:21107-12, 2013.


Buchta, C.M. and Bishop, G.A. TRAF5 negatively regulates TLR signaling in B lymphocytes.  J. Immunol. 192:145-150, 2014.


Ontiveros, E.P., Halwani, A., Stunz, L.L., Kamberos, N., Olivier, A.K., Janz, S., and Bishop, G.A.  A new model of LMP1-MYC interaction in B cell lymphoma.  Leukemia and Lymphoma 55:2917-2923, 2014. 


Yi, Z., Stunz, LL, and Bishop, GA. CD40-mediated maintenance of immune homeostasis in the adipose tissue microenvironment.  Diabetes 63:2751-2760, 2014.


Yi, Z., Lin, W., Stunz, LL, and Bishop, GA. TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating IL-2 receptor signaling.  Nature Immunology 15:866-874, 2014.


Yi, Z., Stunz, LL, Lin, W and. TRAF3 regulates homeostasis of CD8+ central memory T cells. PLoS On3 9:e102120, 2014.


Stunz, L.L. and Bishop, G.A. LMP1 and the B lymphocyte – a complex relationship.  CRC Crit. Rev. Immunol. 34:177-198, 2014.

Yi, Z., Lin, W.W., Stunz, L.L. and Bishop, G.A. Roles for TRAF3 in lymphocyte functions.  Cytokine & Growth Factor Reviews 25:146-156, 2014.

Buchta, C.M. and Bishop, G.A. TLR signaling to B lymphocytes: Functions and mechanisms.  Immunol. Res. 59: 12-22, 2014.

Bishop, G.A. Introduction to immunology at The University of Iowa. Immunol. Res. 59: 1-2, 2014.

Bankert, K.C., Oxley, K.L., Smith, S.M., Graham, J.P., de Boer, M.S., Thweissen, M., Simons, P.J. and Bishop, G.A. Induction of an altered CD40 signaling complex by an antagonistic human mAb to CD40. J. Immunol., in press, 2015.


Yi, Z. and Bishop, G.A. Regulatory role of CD40 in obesity-induced insulin resistance.  Adipocyte 4:1-5, 2015.

Lin, W. W., Hostager, B.S. and Bishop, G.A. TRAF3, ubiquitination and B lymphocyte regulation.  Immunol. Res., in press, 2015.

Bishop, G.A. Yes, we need PhD immunologists.  Invited commentary for Trends Immunol, in press, 2015. 

Yi, Z., Wallis, A.M. and Bishop, G.A.  Roles of TRAF3 in T cells: Many surprises.  Cell Cycle 14:1156-1163, 2015.