The following papers were generated by students from Graduate Course Free Radicals in Biology and Medicine (77:222) 2005.
Instructors
- Garry R. Buettner, Ph.D.
- Larry W. Oberley, Ph.D.
Please Note
In view of the possibility of human error or changes in our knowledge due to continued research, neither the authors nor The University of Iowa nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirmthe information contained herein with
other sources.
All material contained in these papers is copyright of the papers' author, or the owner of the source that the material was taken from. These works are not intended as threats to the ownership of said copyrights.
Paper 1
|
Author
| Title
| pdf |
| Bond, Elena, L. |
Understanding HNE: Chemistry, Biochemistry, and Detection |
 |
| Chen, Chang-Ming |
tert-Butyl hydroperoxide: An Overview |
|
| Dayal, Disha |
An Introduction to Singlet Oxygen Chemistry |
|
| Du, Changbin |
Protein Hydroperoxide |
|
| Eastvold, Joshua S. |
Hypothiocyanous Acid: An Overview |
|
| Hadzic, Tanja |
Hypochlorous Acid |
|
| Hitchler, Michael J. |
A Radical View of Genomic Damage: DNA Peroxidation |
|
| Hummel, Stephen G. |
Danger: Lipid Alkoxyl Radicals Detrimental Biochemical Implications |
|
| Jetawattana, Suwimol |
Malondialdehyde (MDA), A Lipid Oxidation Product. |
|
| Liu, Annie |
Lipid Hydroperoxides (LOOHs) |
|
| Nydegger, Irma |
S-Nitrosothiols |
|
| Owens, Kjerstin M. |
Tocopheroxyl Radiccal |
|
| Pedersen, Katrina S.M. |
Reacting with β-Carotene: A Radical Approach |
|
| Zagorodna, Oksana |
Peroxynitrite: An Overview |
|
| Zhang, Liang |
Sulfenic Acids |
|
Paper 2
|
Author |
Title
|
pdf
|
| Bond, Elena, L. |
The Significance of Zinc in Antioxidant Processes |
|
| Chen, Chang-Ming |
Lactate- A Potential Antioxidant |
|
| Dayal, Disha |
Glutathione: A Multifunctional Tripeptide |
|
| Du, Changbin |
Nitroxides as Antioxidants, Beyond Spin Probes |
|
| Eastvold, Joshua S. |
Mangansese-containing SOD Mimetics |
|
| Hadzic, Tanja |
N-Acetyl-L-Cysteine |
|
| Hitchler, Michael J. |
Antioxidant Chemistry of Trpanothione |
|
| Hummel, Stephen G. |
Episode II: Return of the Antioxidant: Nitric Oxide |
|
| Jetawattana, Suwimol |
Lycopene, a Powerful Antioxidant |
|
| Liu, Annie |
Glutathione Peroxidase Mimics: Ebselen |
|
| Nydegger, Irma |
Selenomethionine; A Unique Antioxidant |
|
| Owens, Kjerstin M. |
The Double Life of Pyruvate |
|
| Pedersen, Katrina S.M. |
Bilirubin Redox Cycling |
|
| Zagorodna, Oksana |
Resveratrol: A Representative of a Phytoalexin Polymeric Family |
|
| Zhang, Liang |
NADPH, A Resource of Electrons |
|
Paper 3
|
Author |
Title
|
pdf
|
| Bond, Elena, L. |
Nonylphenol:
The Feminizing Free Radical Generator
|
|
| Chen, Chang-Ming |
Bleomycin
- Its Activation and DNA Damage
|
|
| Dayal, Disha |
Environmental
Xenobiotic: Cigarette Smoke |
|
| Du, Changbin |
Paraquat,
Toxicity and Mechanism |
|
| Eastvold, Joshua S. |
Acetaminophen
Hepatotoxicity:
Underlying Mechansims of Toxicity and the Protective Role of N-Acetylcysteine |
|
| Hadzic, Tanja |
Asbestos:
Don't Inhale
|
|
| Hitchler, Michael J. |
The
Bubble's Burst: Sonochemistry and Free Radicals |
|
| Hummel, Stephen G. |
Nitroglycerin:
Exploding Biology |
|
| Jetawattana, Suwimol |
Sulfur
Dioxide, Source of Bisulfite |
|
| Liu, Annie |
Misonidazole:
A Bioreductice Marker of Hypoxia |
|
| Nydegger, Irma |
Radon:
Dr. Jekyll or Mr. Hyde? |
|
| Owens, Kjerstin M. |
The
Redox Cycling of PCB Quinones |
|
| Pedersen, Katrina S.M. |
2,3,7,8-Tetrachlorodibenzo-p-dioxin:
Putting the 'ox' in Toxin |
|
| Zagorodna, Oksana |
Lead:
Detection, Absorption, Oxidative Effect and Antioxidant Treatment in Human
Organism |
|
| Zhang, Liang |
Adriamycin
and Its "Heart-breaking" Free Radical Formation |
|
Paper 4- Slide Presentation
|
Author |
Title
|
pdf
|
| Bond, Elena, L. |
Microperoxidase-11 |
|
| Chen, Chang-Ming |
Ribonucleotide Reductase - An Enzyme That Catalyzes Free Radical Reactions |
|
| Dayal, Disha |
Glutathione Disulfide Reductase : Reducing Oxidative Stress |
|
| Du, Changbin |
1-cys Peroxiredoxin |
|
| Eastvold, Joshua S. |
Dual-Domain Oxidase 2 (Duox2): A Non-phagocytic NADPH Oxidase Homologue |
|
| Hadzic, Tanja |
Thioredoxin (Trx) |
|
| Hitchler, Michael J. |
Oxidative Control of DNA Repair: Radiation Effects on Ku |
|
| Hummel, Stephen G. |
iNOS: An Effecter in Immune Response |
|
| Jetawattana, Suwimol |
Hypoxia-Inducible Factor |
|
| Liu, Annie |
GPx-1: An Important Primary Antioxidant Enzyme |
|
| Nydegger, Irma |
Ascorbate Oxidase |
|
| Owens, Kjerstin M. |
NADPH Oxidase in Neutrophils |
|
| Pedersen, Katrina S.M. |
Succinate Dehydrogenase: A Source of Radicals? |
|
| Zagorodna, Oksana |
p53: Redox Regulation |
|
| Zhang, Liang |
NOS-1, A Double-Faced Enzyme |
|
Paper 5
|
Author |
Title
|
pdf
|
| Bond, Elena, L. |
Further Identifying Free Radical Contributions to Sickle Cell Disease |
|
| Chen, Chang-Ming |
Radiation Injury and Hydrogen Peroxide |
|
| Dayal, Disha |
Understanding Diabetes From a New Perspective: The Role of Free Radicals |
|
| Du, Changbin |
Controlling Tumor Growth By Modulating Endogenous H2O2 |
|
| Eastvold, Joshua S. |
Innate Immunity: The Role of the NADPH Oxidase Dual-oxidase 2 (DUOX2) |
|
| Hadzic, Tanja |
Malaria and Reactive Oxygen Species: The Dance of Death |
|
| Hitchler, Michael J. |
Free Radical Control of Senescence |
|
| Hummel, Stephen G. |
Atherosclerosis: Oxidative Modifications of Low Density Lipoproteins |
|
| Jetawattana, Suwimol |
Thalassemias, Disorders of Hemoglobin Synthesis |
|
| Liu, Annie |
Ischemia-Reperfusion Injury in Cardiovascular Systems |
|
| Nydegger, Irma |
HIV and AIDS Dementia: A Killer in Disguise! |
|
| Owens, Kjerstin M. |
Down's Syndrome and Cancer |
|
| Pedersen, Katrina S.M. |
The Chicken or the Egg: ROS and Aß Plaques in Alzheimer's Brains |
|
| Zagorodna, Oksana |
Thyroid Gland: Intrathyroidal Metabolism, Oxidative Stress, and Free Radicals |
|
| Zhang, Liang |
Free Radicals in the Ischemia/Reperfusion Injury of Liver |
|
Appendix
|
Author |
Title
|
pdf
|
| Buettner, Garry R. |
The
Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, a-Tocopherol,
and Ascorbate Arch Biochem Biophys 1993, 300: 535-543 |
|
| Schaefer, Freya Q. et al. |
Redox
Environment of the Cell as Viewed through the Redox State of the Glutathione
Disulfide/Glutathione Couple Free Radic Biol Med 2001,
30: 1191-1212 |
|
| Hempel, Stephen L. et al. |
Dihydrofluorescein
Diacetate Is Superior for Detecting Intracellular Oxidants: Comparison
with 2',7'- Dichlorodihydrofluorescein Diacetate, 5(and 6)-Carboxy-2',7'-Dichlorodihydrofluorescein
Diacetate, and Dihydrorhodamine 123 Free Radic Biol Med 1999,
27: 146-159 |
|
| Qian, Steven Yue et al. |
Iron
and Dioxygen Chemistry Is an Important Route to Initiation of Biological
Free Radical Oxidations: An Electron Paramagnetic Resonance Spin Trapping
Study Free Radic Biol Med 1999, 26: 1447-1456 |
|
| Venkataraman, Sujatha et al. |
Detailed
Methods for the Quantification of Nitric Oxide in Aqueous Solutions Using
Either an Oxygen Monitor or EPR Free Radic Biol Med 2000, 29:
580-585 |
|
| Kelley, Eric E. et al. |
Relative
a-Tocopherol Deficiency in Cultured Cells: Free Radical-Mediated Lipid Peroxidation,
Lipid Oxidizability, and Cellular Polyunsaturated Fatty Acid Content Arch Biochem Biophys 1995, 319: 102-109 |
|
| Wagner, Brett A. et al. |
Vitamin
E Slows the Rate of Free Radical-Mediated Lipid Peroxidation in Cells Arch Biochem Biophys 1996, 334: 261-267 |
|
