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• Nomenclature

• Heavy Chain Isotypes and Allotypes
• Light Chain Isotypes & Allotypes
• Variable Heavy Chain and Light Chain Genes
• Fc Receptors

• Active Investigators

• Reagents

• Antibodies
• Reference Standards

• Biological Properties

Nomenclature:

• Heavy Chain Isotypes and Allotypes

Nomenclature for the C_H genes of the channel catfish¹ [ 04-16-02]

1)       Curators Greg Warr and Eva Bengtén

2)       The only expressed IgM gene is m1. The m2 (IGHM2P) and m3 (IGHM3P) are pseudo IgM genes, with stop codons and large deletions in the exons.

3)       Based on sequence data from individual catfish, not mating experiments

Ghaffari, S.H. and Lobb, C.J.  (1989) Nucleotide sequence of channel catfish heavy chain cDNA and genomic blot analyses.  Implications for the phylogeny of Ig heavy chains.  J. Immunol.  143, 2730-2739.

Wilson, M.R., Marcuz, A., vanGinkel, F., Miller, N.W., Clem, L.W., Middleton, D. and Warr, G.W.  (1990).  The immunoglobulin M heavy chain constant region gene of the channel catafish, Ictalurus punctatus: an unusual mRNA splice pattern produces the membrane form of the molecule. Nucleic Acids Res. 18, 5227-5233.

Wilson, M., Bengtén, E., Miller, N.W., Clem, L.W., Du Pasquier, L., Warr, G.W.  (1997).  A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD.  Proc. Natl. Acad. Sci. USA.  94, 4593-4597.

Ghaffari, S.H., and Lobb, C.J.  (1999).  Structure and genomic organization of a second cluster of immunoglobulin heavy chain gene segments in the channel catfish.  J. Immunol.  162, 1519-1529.

Bengtén, E., Quiniou, S. M.-A., Katagiri, T., Miller, N.W., Clem, L.W., Warr, G.W., Wilson, M.W. The IgH Locus of the Channel Catfish, Ictalurus punctatus, Contains Multiple Constant Region Gene Sequences: Different Genes Encode Heavy Chains of Membrane and Secreted IgD. Submitted for publication

Atlantic Cod C_H Nomenclature¹ [04-19-2002] 

1) Curator Lars Pilström

References

Bengtén, E., Leanderson, T. and Pilström, L. (1991) Immunoglobulin heavy chain cDNA from the teleost Atlantic cod (Gadus morhua L.): nucleotide sequences of secretory and membrane form show unusual splicing pattern. Eur. J. Immunol. 21: 3027-3033

Stenvik, J. and Jørgensen, T. Ø. (2000) Immunoglobulin D (IgD) of Atlantic cod has a unique structure. Immunogenetics 51:452-461

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• Light Chain Isotypes & Allotypes

Channel Catfish C_H Nomenclature¹         [04-16-02]

1)  Curators Greg Warr and Eva Bengtén

2)  The only expressed IgM gene is m1. The m2 (IGHM2P) and m3 (IGHM3P) are pseudo IgM genes, with stop codons and large deletions in the exons.

3)  Based on sequence data from individual catfish, not mating experiments

References

Ghaffari, S.H. and Lobb, C.J.  (1989) Nucleotide sequence of channel catfish heavy chain cDNA and genomic blot analyses.  Implications for the phylogeny of Ig heavy chains.  J. Immunol.  143, 2730-2739.

Wilson, M.R., Marcuz, A., vanGinkel, F., Miller, N.W., Clem, L.W., Middleton, D. and Warr, G.W.  (1990).  The immunoglobulin M heavy chain constant region gene of the channel catafish, Ictalurus punctatus: an unusual mRNA splice pattern produces the membrane form of the molecule. Nucleic Acids Res. 18, 5227-5233.

Wilson, M., Bengtén, E., Miller, N.W., Clem, L.W., Du Pasquier, L., Warr, G.W.  (1997).  A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD.  Proc. Natl. Acad. Sci. USA.  94, 4593-4597.

Ghaffari, S.H., and Lobb, C.J.  (1999).  Structure and genomic organization of a second cluster of immunoglobulin heavy chain gene segments in the channel catfish.  J. Immunol.  162, 1519-1529.

Bengtén, E., Quiniou, S. M.-A., Katagiri, T., Miller, N.W., Clem, L.W., Warr, G.W., Wilson, M.W. The IgH Locus of the Channel Catfish, Ictalurus punctatus, Contains Multiple Constant Region Gene Sequences: Different Genes Encode Heavy Chains of Membrane and Secreted IgD. Submitted for publication.

Atlantic Cod C_L Nomenclature¹    [04-19-2002]  

The Ig light chain locus in teleost fish has a multicluster form of organization i.e. the V-J-C segments are repeated in the genome so it is not quite clear if each cluster should be considered as a separate locus or alleles. Here the word alleles have been used because all the C segments sequenced today vary to a similar degree as alleles would do.

1)  Curator Lars Pilström

References

Pilström, L., Lunqvist, M. L. & Wermenstam, N. E.: (1998) The immunoglobulin light chain in poikilothermic vertebrates. Immunological Reviews 166, 123-132,

Bengtén, E., Wilson, M., Miller, N., Clem, L. W., Pilström, L., and Warr, G. W. (2002) Immunoglobulin Isotypes in Phylogeny. in L. Du Pasquier and G. W. Litman (eds.) Origin and Evolution of the Vertebrate immune System.. Curr. Topics Microbiol. Immunol. 248, 189-219 (2000)

Pilström, L.: The mysterious immunoglobulin light chain. Dev. Comp. Immunol. 26, 207-215,

Daggfeldt, A., Bengtén, E. & Pilström, L.: (1993) A cluster type organization of the loci of the immunoglobulin light chain in Atlantic cod (Gadus morhua L.) and rainbow trout (Oncorhynchus mykiss Walbaum) indicated by nucloetide sequences of cDNA and hybridization analysis. Immunogenetics 38: 199-209

Bengtén, E., Strömberg, S., Daggfeldt, A. Magor, B. G. & Pilström, L.: (2000) Transcriptional enhancers of immunoglobulin light chain genes in Atlantic cod (Gadus morhua). Immunogenetics 51: 647-658.

Wermenstam, N. E. & Pilström, L.: (2002) Unpublished.

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• Variable Heavy Chain and Light Chain Genes

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• Fc recepters

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Active Investigators:

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Reagents:

• Antibodies

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• Reference Standards

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Biological Properties:

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